生物活性

• 描述Ranitidine Hydrochloride is an H2-antagonist that suffers from low oral bioavailability of 50%, but the selected ranitidine HCl floating-bioadhesive tablets could be regarded as a promising gastroretentive drug delivery system that could deliver the drug at a controlled rate^[3]. Ranitidine is a selective, competitive histamine H2-receptor antagonist used in the short-term treatment of active duodenal ulcers and gastric hypersecretory conditions. Ranitidine is four to ten times more potent than cimetidine on a molar basis in inhibiting stimulated gastric acid secretion^[4]. Ranitidine hydrochloride had no effects on fetal and postnatal development, general behavior and various functions of F1 generation at the dose of 40 mg/kg/day or less^[5]. At dose of 400 mg/kg/day, ranitidine hydrochloride showed no effects on dams, excepting slight suppression in body weight gain in early period of administration. Ranitidine hydrochloride induced no increase in incidence of visceral and skeletal variations. Ranitidine hydrochloride had no teratogenic effect on rabbits at dose of 400 mg/kg/day or lower than that^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02655458	Multiple Myeloma	Phase 1	Completed	-	United States, New York ... more >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse <<
  NCT02125604	Relapsing-Remitting Multiple S... more >>clerosis Collapse <<	Phase 4	Completed	-	Germany ... more >> Research Site Augsburg, Germany Research Site Bamburg, Germany Research Site Bayreuth, Germany Research Site Berlin, Germany Research Site Bochum, Germany Research Site Bonn, Germany Research Site Erbach, Germany Research Site Erlangen, Germany Research Site Freiburg, Germany Research Site Hamburg, Germany Research Site Leipzig, Germany Research Site Marburg, Germany Research Site Minden, Germany Research Site Mittweida, Germany Research Site Munchen, Germany Research Site Munster, Germany Research Site Osnabruck, Germany Research Site Potsdam, Germany Research Site Siegen, Germany Collapse <<
  NCT01017198	Advanced Solid Tumors	Phase 1	Completed	-	United States, Arizona ... more >> Reseach Facility Scottsdale, Arizona, United States United States, California Reseach Facility Encinitas, California, United States United States, Texas Reseach Facility San Antonio, Texas, United States Collapse <<

• 更多
• 参考文献

• [1] Luyendyk JP, Maddox JF, et al. Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J Pharmacol Exp Ther. 2003 Oct;307(1):9-16.

  [2] Herling AW, Becht M, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb;20(1-2):35-9.

  [3] Abduljabbar HN, Badr-Eldin SM, Aldawsari HM. Gastroretentive Ranitidine Hydrochloride Tablets with Combined Floating and Bioadhesive Properties: Factorial Design Analysis, In Vitro Evaluation and In Vivo Abdominal X-Ray Imaging. Curr Drug Deliv. 2015;12(5):578-90

  [4] Gaginella TS, Bauman JH. Ranitidine hydrochloride. Drug Intell Clin Pharm. 1983 Dec;17(12):873-85

  [5] Kamada S, Sakanoue M, Takeuchi M, Shimpo K, Tanabe T. [Effects of intravenous administration of ranitidine hydrochloride to the pregnant rat in organogenesis period]. J Toxicol Sci. 1984 Jun;9 Suppl 1:29-52. Japanese

  [6] Tamura J, Sato N, Ezaki H, Yokoyama S. [Teratological study on ranitidine hydrochloride in rabbits]. J Toxicol Sci. 1983 Jan;8 Suppl 1:141-50. Japanese

• 更多

• Collapse