|N-(4-(N-(4-硝基苯基)氨磺酰基)苯基)乙酰胺|CsnPharm

CAS No.: 122-16-7

磺胺硝苯 Catalog No. CSN12009

Synonyms: NSC-217299;磺胺硝苯

Sulfanitran is a sulfonamide antibiotic which is used in the poultry industry and can stimulate the ATP binding cassette family transporter multidrug resistance protein 2 (MRP2).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Sulfanitran is a sulfonamide antiinfective drug. Sulfanitran, MRP2 (Multidrug resistance protein 2) stimulators, strongly increased the affinity of MRP2 for E217betaG (estradiol-17-beta-d-glucuronide) (half-maximal transport rates at 65 and 16 microm E217betaG, respectively) and shifted the sigmoidal dependence of transport rate on substrate concentration to a more hyperbolic one, without substantially affecting the maximal transport rate. Sulfanitran also stimulated MRP2 activity in cells, i.e. the transport of saquinavir through monolayers of Madin-Darby canine kidney II cells^[2]. In MDCK cells stably expressing human MRP2 or mouse Mrp2, saquinavir and docetaxel were more efficiently transported by mouse Mrp2, whereas vinblastine was transported better by human MRP2. MRP2/Mrp2-mediated transepithelial transport of several drugs could be stimulated by probenecid and sulfanitran, but stimulation was often more pronounced for human MRP2 than for mouse Mrp2^[3].
参考文献

[1] Determination of sulfanitran in animal feeds and pre-mixes. Analyst. 1977 Nov;102(1220):869-72.
[2] Zelcer N, Huisman MT, Reid G, et al. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003;278(26):23538‐23544
[3] Zimmermann C, van de Wetering K, van de Steeg E, Wagenaar E, Vens C, Schinkel AH. Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos. 2008;36(4):631‐640

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9821 mL
- 14.9105 mL
- 29.8209 mL
- 5 mM
- 0.5964 mL
- 2.9821 mL
- 5.9642 mL
- 10 mM
- 0.2982 mL
- 1.4910 mL
- 2.9821 mL

技术信息

CAS号

122-16-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H13N3O5S

运输

蓝冰

分子量

335.34

别名

NSC-217299;磺胺硝苯

溶解度

DMSO	260.0 mg/mL (775.3 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

磺胺硝苯 Catalog No. CSN12009

靶点选择性

请登录您的专属账户

确认信息