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CAS No.: 19408-84-5

二氢辣椒碱 Catalog No. CSN12791

Synonyms: 二氢辣椒碱;二氢辣椒素

Dihydrocapsaicin, a natural product isolated and purified from the fruits of Capsicum annuum L..

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400-920-2911

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描述Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection. Dihydrocapsaicin displayed the strongest inhibitory activity against epidermal growth factor (EGF)-induced neoplastic transformation. Dihydrocapsaicin specifically suppressed EGF-induced phosphorylations of the p70S6K1-S6 pathway and the expression of c-Fos. A reduction in c-Fos levels by dihydrocapsaicin led to a concomitant downregulation of AP-1 activation. Dihydrocapsaicin can block amino acid-dependent mechanistic targets of rapamycin complex 1 (mTORC1)-p70S6K1-S6 signal activation. Additionally, dihydrocapsaicin was able to selectively augment amino acid deprivation-induced cell death in mTORC1-hyperactive cells^[3]. Melanoma A375 and MV3 cell lines were treated with DHC (Dihydrocapsaicin) and the cell proliferation, migration, and invasion were significantly suppressed. Furthermore, DHC effectively inhibited xenograft tumor growth and pulmonary metastasis of melanoma cells in NOD/SCID mice model. DHC accelerates ubiquitination of β-catenin and up-regulates the beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) in melanoma cells^[4]. Dihydrocapsaicin treatment was found to significantly improve neuronal density, decrease infarct volume, reduce MDA elevation, improve CAT and SOD activities, decrease the density ratio of Bax and caspase-3, and increase the density ratio of Bcl-XL to β-actin in the cerebral cortex and hippocampus^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2528 mL
- 16.2640 mL
- 32.5280 mL
- 5 mM
- 0.6506 mL
- 3.2528 mL
- 6.5056 mL
- 10 mM
- 0.3253 mL
- 1.6264 mL
- 3.2528 mL

技术信息

CAS号	19408-84-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H29NO3	运输	蓝冰
分子量	307.43	别名	二氢辣椒碱;二氢辣椒素

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