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CAS No.: 314054-00-7

N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide Catalog No. CSN22907

Synonyms: STING inhibitor C-176

C-176 is a STING inhibitor with anti-inflammatory effection.

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实验方案

技术信息

生物活性

描述Stimulator of interferon genes (STING) is an intracellular signaling molecule that senses cytosolic DNA to regulate the production of type I interferons (IFNs) and other inflammatory cytokines. C-176 is a covalent STING inhibitor that effectively decreases STING-mediated IFNβ reporter activity at the dosage of 0.01 – 1.25 μM. Treatment of [³H]-palmitate labelled HEK293T cells with 1 μM C-176 inhibited STING palmitoylation. In wild-type C57BL/6J mice, pretreatment with 750 nmol C-176 for 1h and 4h resulted in a significant reduction of STING agonist-induced IFNs and IL-6 production in serum. Two-week injection of Trex1 deficient mice with C-176 (7.5 μL/day) significantly decreased serum levels of type I IFNs and suppressed cardiac inflammatory parameters. Treatment with C-176 in Trex1^-/- mice for three months attenuated systemic inflammatory signs in smooth muscle, tongue and stomach^[1].
作用机制C-176 is a nitrofuran derivative that acts as a STING inhibitor by covalently binding to the Cys91 of mouse STING^[1].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01308658	Healthy	Phase 1	Completed	-	Germany ... more >> Berlin, Germany Collapse <<

参考文献

[1] Haag SM, Gulen MF, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018;559(7713):269-273.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7926 mL
- 13.9630 mL
- 27.9259 mL
- 5 mM
- 0.5585 mL
- 2.7926 mL
- 5.5852 mL
- 10 mM
- 0.2793 mL
- 1.3963 mL
- 2.7926 mL

技术信息

CAS号

314054-00-7

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H7IN2O4

运输

蓝冰

分子量

358.09

别名

STING inhibitor C-176

溶解度

DMSO	98.0 mg/mL (273.7 mM)
Water	insoluble

动物实验配方

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N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide Catalog No. CSN22907

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