|N-[6-(2-氨基苯基氨基)-6-氧代己基]-4-甲基苯甲酰胺|CsnPharm

CAS No.: 1215493-56-3

N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide Catalog No. CSN17367

Synonyms: RGFP109

RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 HDAC1

IC50:60nM HDAC3

IC50:50nM
描述A few studies find that abnormal histone deacetylation may play a role in the dyskinetic phenotype or Friedreich's Ataxia. RG2833, also called as RGFP109, is an HDAC1/3 inhibitor with IC50 value of 60nM and 50nM (measured by purified recombinant HDAC enzymes), respectively^[1]. RG2833 mainly used in the research of dyskinetic phenotype is partially due to its BBB penetration. ChIP analysis showed increased level of the acetylated H3K9, H4K5 residues within the FXN locus of brain tissue from YG8R FRDA mice (Friedreich ataxia model) given subcutaneous injections of 100mg/kg RGFP109 ﬁve times per week for 5 months. Meanwhile, a 2.6-fold increase in frataxin expression of brain tissue and the improved locomotor activity can also be observed in YG8R FRDA mice compared with control^[2]. Another study show that though 30mg/kg orally treatment of RGFP109 for 6 days had no acute effect on dyskinesia of the parkinsonian marmoset, one week following cessation of RGFP109, dyskinesia and duration of ON-time with disabling dyskinesia were reduced by 37% and 50%, respectively, compared with L-DOPA alone^[3].
作用机制The ortho-aminoanilide structure of RG2833 is the zinc-binding moiety. ^[4]
动物研究
剂量
Mice: 150 mg/kg^[1]

给药途径
s.c.

动物研究
剂量	Mice: 150 mg/kg^[1]
给药途径	s.c.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9461 mL
- 14.7305 mL
- 29.4610 mL
- 5 mM
- 0.5892 mL
- 2.9461 mL
- 5.8922 mL
- 10 mM
- 0.2946 mL
- 1.4731 mL
- 2.9461 mL

技术信息

CAS号

1215493-56-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H25N3O2

运输

蓝冰

分子量

339.43

别名

RGFP109

溶解度

DMSO	440.0 mg/mL (1296.3 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	9 mg/mL	clear
PO	0.5% CMC-Na	37 mg/mL	suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

靶点	Description	IC50
HDAC1		IC50:60nM
HDAC3		IC50:50nM

N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide Catalog No. CSN17367

靶点选择性

请登录您的专属账户

确认信息