|N-((2R,3R,4S,5R)-3,5,6-三羟基-1-氧代-4-(((2S,3R,4S,5R,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)己-2-基)乙酰胺|CsnPharm

CAS No.: 32181-59-2

N-Acetyllactosamine/N -乙酰- D- 乳糖胺 Catalog No. CSN28933

Synonyms: LacNAc;N-acetyl-D-Lactosamine;N-乙酰-D-乳糖胺

N-acetyl-D-Lactosamine is a disaccharide consisting of galactose and N-acetylglucose. It occurs naturally as a structural element in a variety of glycoconjugates. N-acetyl-D-Lactosamine is used to characterize lectins.

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生物活性

描述N-acetyl-D-Lactosamine is a disaccharide consisting of galactose and N-acetylglucose. It occurs naturally as a structural element in a variety of glycoconjugates. N-acetyl-D-Lactosamine is used to characterize lectins. N-Acetyl-D-lactosamine (LacNAc, Galβ1,4GlcNAc) is found in breast milk as a free disaccharide. This compound is also found as a component of human milk oligosaccharides (HMOs), which have repeating and variably branched lactose and/or LacNAc units, often attached to sialic acid and fucose monosaccharides^[1]. The lectin was affected by denaturing agents such as urea (2 M: ), thiourea (2 M: ) and guanidine-HCl (0.5 M: ) and did not require Ca2+ and Mn2+ for its activity. It was a potent mitogen at 10 microg/ml towards human peripheral blood mononuclear cells with 50% growth inhibitory potential towards SiHa (human cervix ) cancer cell line at 100 microg/ml^[2]. The lectins were inhibited by N-acetyl-D-lactosamine (LacNAc), a disaccharide and asialofetuin, a complex desialylated serum glycoprotein. A. intermedium showed antiproliferative effect against various human cancer cell lines in vitro^[3].
参考文献

[1] Arnold JW, Whittington HD, Dagher SF, Roach J, Azcarate-Peril MA, Bruno-Barcena JM. Safety and Modulatory Effects of Humanized Galacto-Oligosaccharides on the Gut Microbiome. Front Nutr. 2021 Apr 7;8:640100
[2] Kaur A, Kamboj SS, Singh J, Saxena AK, Dhuna V. Isolation of a novel N-acetyl-D-lactosamine specific lectin from Alocasia cucullata (Schott.). Biotechnol Lett. 2005 Nov;27(22):1815-20
[3] Kaur M, Singh J, Kamboj SS, Singh J, Kaur A, Sood SK, Saxena AK. Isolation and characterization of two N-acetyl-D-lactosamine specific lectins from tubers of Arisaema intermedium Blume and A. wallichianum Hook f. Indian J Biochem Biophys. 2005 Feb;42(1):34-40

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6086 mL
- 13.0430 mL
- 26.0859 mL
- 5 mM
- 0.5217 mL
- 2.6086 mL
- 5.2172 mL
- 10 mM
- 0.2609 mL
- 1.3043 mL
- 2.6086 mL

技术信息

CAS号	32181-59-2	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H25NO11	运输	蓝冰
分子量	383.35	别名	LacNAc;N-acetyl-D-Lactosamine;N-乙酰-D-乳糖胺

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