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CAS No.: 2508-72-7

安他唑啉盐酸盐 Catalog No. CSN18662

Synonyms: Phenazoline hydrochloride;Phenazocine HCl;Antazoline (hydrochloride)

Antazoline HCl is a antihistamine with anticholinergic properties. It is used to relieve nasal congestion.

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生物活性

描述Antazoline HCl is a first-generation antihistamine with antiarrhythmic properties. Antazoline significantly reduced induction of VF (ventricular fibrillation) in an experimental model of acquired SQTS(short-QT-syndrome). In three experimental models of acquired LQTS( long-QT-syndrome), antazoline effectively suppressed TdP(Torsade de pointes) ^[3]. Intravenous antazoline was effective and safe in the rapid conversion of non-valvular paroxysmal atrial fibrillation to sinus rhythm in patients without heart failure^[4]. Antazoline safely and rapidly converts AF (atrial fibrillation) into sinus rhythm during ablation of AP(accessory pathways). The drug does not block AP completely, enabling continuation of ablation^[5]. After a single intravenous administration at 10 mg/kg to rats, plasma concentration profile showed a relative fast elimination proceeding with a terminal elimination half-life of 3.53 h. Approximately 61.8 and 14.2% of the administered dose were recovered in urine and bile after 72 and 24 h post-dosing respectively; 5.9% of the administered dose was recovered in feces after 72 h post-dosing. The above results show that the major elimination route is urinary excretion^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01527279	Paroxysmal Atrial Fibrillation	Phase 4	Completed	-	Poland ... more >> Institute of Cardiology, II Dept. of Coronary Heart Disease Warsaw, Poland, 02-637 Collapse <<
NCT01380678	Pterygium Inf... more >>lammation Collapse <<	Phase 3	Unknown	December 2012	Thailand ... more >> Srinagarind Hospital Recruiting Mueng, Khon Kaen, Thailand, 40000 Contact: Olan Suwan-apichon, MD Collapse <<
NCT01380678	Pterygium Inf... more >>lammation Collapse <<	Phase 3	Unknown	December 2012	Thailand ... more >> Srinagarind Hospital Recruiting Mueng, Khon Kaen, Thailand, 40000 Contact: Olan Suwan-apichon, MD Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3133 mL
- 16.5665 mL
- 33.1330 mL
- 5 mM
- 0.6627 mL
- 3.3133 mL
- 6.6266 mL
- 10 mM
- 0.3313 mL
- 1.6567 mL
- 3.3133 mL

技术信息

CAS号

2508-72-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H20ClN3

运输

蓝冰

分子量

301.81

别名

Phenazoline hydrochloride;Phenazocine HCl;Antazoline (hydrochloride);2-(N-Benzylanilinomethyl)-2-imidazoline Hydrochloride;Antasten;Phenazoline;Antihistal;Antastan;Antistin;Antazoline HCl

溶解度

DMSO	40.0 mg/mL (132.5 mM) warming
Water	55.0 mg/mL (182.2 mM)

动物实验配方

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安他唑啉盐酸盐 Catalog No. CSN18662