|N-甲基甘氨酸|CsnPharm

CAS No.: 107-97-1

肌氨酸 Catalog No. CSN15699

Synonyms: N-Methylglycine;Sarcosin;Sarcosinic Acid

Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.

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技术信息

生物活性

描述Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function^[3]. Sarcosine, similar to other NMDA receptor-activating agents, is an effective adjuvant in the treatment of schizophrenia. Because sarcosine facilitates NMDA receptor function, it may affect the seizure threshold. In the iv PTZ test, sarcosine did not exert a significant effect on the seizure threshold at any of the doses tested (100, 200, 400 and 800 mg/kg, ip). However, at doses of 400 and 800 mg/kg, sarcosine significantly raised the threshold for electroconvulsions^[4]. Using whole-cell recordings from cultured embryonic mouse hippocampal neurons found that sarcosine evoked a dose-dependent, strychnine sensitive, Cl(-) current that cross-inhibited glycine currents. Sarcosine evoked this current with Li(+) in the extracellular solution to block GlyT1, in neurons treated with the essentially irreversible GlyT1 inhibitor N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS), and in neurons plated in the absence of glia^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02404337	Homocystinuria	Phase 2	Completed	-	France ... more >> Assistance Publique - Hôpitaux de Paris Paris, France, 75019 Collapse <<
NCT01818830	-	-	Unknown	-	China, Beijing ... more >> Chinese PLA General Hospital Beijing, Beijing, China, 100853 Collapse <<
NCT03194659	Pregnancy	Not Applicable	Recruiting	December 2019	United States, New York ... more >> Human Metabolic Research Unit, Cornell University Recruiting Ithaca, New York, United States, 14853 Contact: Erica Bender, MSN, CNM 607-255-9417 eb572@cornell.edu Principal Investigator: Marie A. Caudill, PhD Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 11.2242 mL
- 56.1210 mL
- 112.2420 mL
- 5 mM
- 2.2448 mL
- 11.2242 mL
- 22.4484 mL
- 10 mM
- 1.1224 mL
- 5.6121 mL
- 11.2242 mL

技术信息

CAS号

107-97-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C3H7NO2

运输

蓝冰

分子量

89.09

别名

N-Methylglycine;Sarcosin;Sarcosinic Acid;Methylaminoacetic Acid;肌氨酸

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02404337	Homocystinuria	Phase 2	Completed	-	France ... more >> Assistance Publique - Hôpitaux de Paris Paris, France, 75019 Collapse <<
NCT01818830	-	-	Unknown	-	China, Beijing ... more >> Chinese PLA General Hospital Beijing, Beijing, China, 100853 Collapse <<
NCT03194659	Pregnancy	Not Applicable	Recruiting	December 2019	United States, New York ... more >> Human Metabolic Research Unit, Cornell University Recruiting Ithaca, New York, United States, 14853 Contact: Erica Bender, MSN, CNM 607-255-9417 eb572@cornell.edu Principal Investigator: Marie A. Caudill, PhD Collapse <<
NCT03416257	-	-	Completed	-	-
NCT03253276	Primary Biliary Cirrhosis	Early Phase 1	Recruiting	March 31, 2018	Denmark ... more >> Susanne Keiding Recruiting Aarhus, Denmark, 8000 Contact: Susanne Keiding, prof +45 30939936 susakeid@rm.dk Contact: Michael Sørensen, PhD + 45 78463033 michsoer@rm.dk Collapse <<
NCT01047592	Schizophrenia	Phase 2	Completed	-	Taiwan ... more >> Changhua Hospital Changhua, Taiwan, 513 Collapse <<
NCT00328276	Schizophrenias ... more >> Psychoses Psychotic Disorders Schizophrenic Disorders Collapse <<	Phase 2	Completed	-	Taiwan ... more >> Department of Psychiatry, China Medical University Hospital Taichung, Taiwan, 404 Collapse <<
NCT00491569	Schizophrenias ... more >> Psychoses Psychotic Disorders Schizophrenic Disorders Collapse <<	Phase 2	Completed	-	Taiwan ... more >> China Medical University Hospital Taichung, Taiwan, 404 Collapse <<
NCT01031927	Obsessive Compulsive Disorder	Phase 2	Completed	-	Taiwan ... more >> China Medical University Hospital Taichung, Taiwan Collapse <<
NCT00977353	Major Depressive Disorder ... more >> Depression Major Depression Collapse <<	Phase 2	Completed	-	Taiwan ... more >> Department of Psychiatry, China Medical University Hospital Taichung, Taiwan Collapse <<
NCT00538070	Schizophrenia	Not Applicable	Completed	-	United States, Massachusetts ... more >> McLean Hospital, Brain Imaging Center Belmont, Massachusetts, United States, 02478 MGH Center for Addiction Medicine Boston, Massachusetts, United States, 02114 Collapse <<
NCT02462447	-	-	Completed	-	United States, Michigan ... more >> University of Michigan Health Systems Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT01785628	Parkinson's Disease With Demen... more >>tia Collapse <<	Not Applicable	Completed	-	Taiwan ... more >> China Medical University Hospital/Neuro Depart. Taichung, Taiwan Collapse <<
NCT00276263	Schizophrenias ... more >> Psychoses Psychotic Disorders Schizophrenic Disorders Collapse <<	Phase 2	Withdrawn(lack of participants... more >>) Collapse <<	-	Israel ... more >> Ezrath Nashim - Herzog Memorial Hospital Jerusalem, Israel, 91035 Department of Psychiatry, Hadassah Hospital and Community Clinics Jerusalem, Israel Collapse <<
NCT01503359	Schizophrenia	Phase 2	Completed	-	Poland ... more >> Central Clinical Hospital Łódź, Czechosłowacka 8/10, Poland, 92-216 Collapse <<
NCT01785628	-	-	Completed	-	-

肌氨酸 Catalog No. CSN15699

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