CAS No.: 656820-32-5
逆转素 Catalog No. CSN15807
Synonyms: 逆转素
Reversine, a synthetic purine analogue(2,6-disubstituted purine), is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Adenosine Receptor A3
Ki:0.66μMAurora Kinase A
IC50:12nMAurora Kinase B
IC50:13nMAurora Kinase C
IC50:20nM- 描述
- 参考文献
- [1] D'Alise AM, Amabile G, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7(5):1140-9.
- [2] Perreira M, Jiang JK, et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 656820-32-5 | 储存条件 |
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| 分子式 | C21H27N7O | 运输 | 蓝冰 | |||||||
| 分子量 | 393.49 | 别名 | 逆转素 | |||||||
| 溶解度 |
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动物实验配方 |
