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CAS No.: 1784-03-8

Nα-Tosyl-L-arginine Methyl Ester HCl/4,5-羟基萘乙烯 Catalog No. CSN23550

Synonyms: N-4-Tosyl-L-arginine methyl ester (hydrochloride);TAME;Tosylarginine methyl ester

TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest[1].

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生物活性

描述The anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit complex that functions as a RING domain E3 ubiquitin ligase to regulate transitions through the cell cycle, achieved by controlling the defined ubiquitin-dependent degradation of specific cell cycle regulators^[1]. Tos-Arg-OMe HCl (TAME) is a kind of amino acid derivatives, is a substrate for trypsin, plasmin, thrombin, and other proteases. It is also an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest^[2]. Cell surface Tos-Arg-OMe esterase activity was inhibited by aprotinin, benzamidine, pentamidine, and a tris-amidine derivative (alpha,alpha',alpha''-tris(3-amidinophenoxy)mesitylene)^[3]. Acetone-kaolin activation of plasma produced the expected 30-fold increase in Tos-Arg-OMe esterase activity but no change in immunoreactive tissue kallikrein levels^[4].
参考文献

[1] David Barford. Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions. Curr Opin Struct Biol.2020 Apr;61:86-97.
[2] S Liu,et al. Integrin cytoplasmic domain-binding proteins. J Cell Sci. 2000. 113 (Pt 20), 3563-71.
[3] J Chao, H S Margolius. Studies on rat renal cortical cell kallikrein. II. Identification of kallikrein as an ecto-enzyme. Biochim Biophys Acta.1979. 570(2), 330-40.
[4] K Shimamoto, R K Mayfield.et al. Immunoreactive tissue kallikrein in human serum. J Lab Clin Med.1984. 103(5), 731-8.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6394 mL
- 13.1970 mL
- 26.3939 mL
- 5 mM
- 0.5279 mL
- 2.6394 mL
- 5.2788 mL
- 10 mM
- 0.2639 mL
- 1.3197 mL
- 2.6394 mL

技术信息

CAS号	1784-03-8	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H23ClN4O4S	运输	蓝冰
分子量	378.87	别名	N-4-Tosyl-L-arginine methyl ester (hydrochloride);TAME;Tosylarginine methyl ester;TAME HCl;TAME Hydrochloride;Ts-Arg-Me Hydrochloride;Ts-Arg-OMe Hydrchloride

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Nα-Tosyl-L-arginine Methyl Ester HCl/4,5-羟基萘乙烯 Catalog No. CSN23550

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