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CAS No.: 27848-84-6

Nicergoline/尼麦角林 Catalog No. CSN16735

Synonyms: FI-6714;Nicotergoline;NSC 150531

Nicergoline is a non-selective alpha-adrenergic receptor antagonist which can decrease vascular resistance and increase arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells.

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描述Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Nicergoline is a potent and selective alpha 1A-adrenoceptor subtype antagonist, an alpha 1-adrenoceptor subtype which is mainly represented in resistance arteries. Nicergoline displaced [3H]-prazosin bound to rat forebrain membranes pretreated with chloroethylclonidine (pKi = 9.9 +/- 0.2) at concentrations 60-fold lower than in rat liver membranes (pKi = 8.1 +/- 0.2)^[3]. Nicergoline ameliorated apoptosis in hippocampal cells and hippocampus tissue in 3xTg-AD mice with Alzheimer's disease. In addition, the expression levels of inflammatory factors, in addition to oxidative stress, were decreased in hippocampal cells treated with nicergoline. Additionally, amyloid precursor protein accumulation was cleared in the hippocampal area in nicergoline-treated mice. Nicergoline inhibited neuronal loss and prevented cognitive impairment through the restoration of learning/memory ability^[4]. Nicergoline treatment improves perfusion of the frontal and parietal regions in early AD patients. It is possible that the increased perfusion in the superior frontal gyrus may be related to the mechanisms that delay or prevent progressive deterioration of cognitive functions in AD^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02374567	Dementia Depr... more >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Collapse <<	Phase 3	Terminated	-	Germany ... more >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Collapse <<
NCT01009476	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0645 mL
- 10.3224 mL
- 20.6447 mL
- 5 mM
- 0.4129 mL
- 2.0645 mL
- 4.1289 mL
- 10 mM
- 0.2064 mL
- 1.0322 mL
- 2.0645 mL

技术信息

CAS号

27848-84-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H26BrN3O3

运输

蓝冰

分子量

484.39

别名

FI-6714;Nicotergoline;NSC 150531;TA-079;Nimergoline;Sermion;尼麦角林

溶解度

DMSO	66.67 mg/mL (137.6 mM)
Water	insoluble

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