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CAS No.: 965-52-6

Nifuroxazide/硝呋齐特 Catalog No. CSN11557

Synonyms: Ambatrol;Antinal;Bacifurane

Nifuroxazide suppresses the transcription activity of STAT1, STAT3 (IC50 = 3 μM in cells) and STAT5. It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections.

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技术信息

生物活性

描述Signal transducers and activators of transcription (STATs) are a family of transcription factors essential for the pathogenesis of many cancers. STAT3 in particular has been found to be a critical mediator in the pathogenesis of many tumors. Nifuroxazide is a potent inhibitor of STAT3 through the inhibition of STAT3 tyrosine phosphorylation. Treatment of myeloma cell lines U266 or INA6 cells with nifuroxazide for 48h resulted in a dose-dependent loss of cell viability with an EC₅₀ of approximately 4.5 μM in both cell lines^[3]. In animal experiments, intraperitoneal administration of 50 mg/kg/day nifuroxazide inhibited 4T1 (the human breast cancer cell line) tumor growth, blocked formation of pulmonary metastases without detectable toxicity and decreased Ki-67, MMP-9 and increased cleaved caspase-3 expression^[4]. Oral administration of nifuroxazide at 25 mg/kg/day to diabetic rats for eight weeks attenuated diabetes induced damage in renal structure, ameliorated oxidative stress, triggered antioxidant defense, educed NF-κB nuclear translocation and cleaved caspase-3 expression and down regulated the activity of apoptotic enzymes (caspase-3/caspase-8/caspase-9) in diabetic kidney^[5].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human U3A cells	-	Function assay	1 h	Inhibition of STAT3 expressed in human U3A cells after 1 hr by luciferase reporter gene assay, EC50=3 μM	22650325

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6335 mL
- 18.1673 mL
- 36.3346 mL
- 5 mM
- 0.7267 mL
- 3.6335 mL
- 7.2669 mL
- 10 mM
- 0.3633 mL
- 1.8167 mL
- 3.6335 mL

技术信息

CAS号

965-52-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H9N3O5

运输

蓝冰

分子量

275.22

别名

Ambatrol;Antinal;Bacifurane;Diafuryl;Diarlidan;硝呋齐特;硝呋酚酰肼

溶解度

DMSO	50.0 mg/mL (181.7 mM)
Water	insoluble

动物实验配方

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