|(R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-羟基-6-(羟甲基)-3,5-二甲基四氢-2H-吡喃-2-基)-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,4,10-三甲基-1,6-二氧杂螺[4.5]癸烷-7-基)甲基)-3-甲基四氢-2H-吡喃-2-基)丙酸钠盐|CsnPharm

CAS No.: 28643-80-3

Nigericin sodium salt/尼日利亚菌素钠盐 Catalog No. CSN11558

Synonyms: Nigericin (sodium salt);NSC 292567;Nigericin Sodium Salt

Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.

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生物活性

描述Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator. Nigericin (0.1 µM) inhibits proliferation, migration, invasion and clonogenicity of H460 lung cancer cells^[3]. A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM) and Fluo3 fluorescence (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM) and cytosolic pH (0.1-1 nM). Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance^[4]. Nigericin could selectively target CSCs (Cancer stem cells) and sensitize CSCs in NPC (Nasopharyngeal carcinoma) to the widely used clinical drug cisplatin both in vitro and in vivo^[5]. Nigericin exhibits great toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μM and 15.86±0.18 μM. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions. HT29 cells treated with nigericin induced an increase in E-cadherin expression and a decrease in the vimentin expression relative to vehicle controls^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3388 mL
- 6.6939 mL
- 13.3879 mL
- 5 mM
- 0.2678 mL
- 1.3388 mL
- 2.6776 mL
- 10 mM
- 0.1339 mL
- 0.6694 mL
- 1.3388 mL

技术信息

CAS号

28643-80-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C40H67NaO11

运输

蓝冰

分子量

746.94

别名

Nigericin (sodium salt);NSC 292567;Nigericin Sodium Salt;Nigericin sodium;Azalomycin M;Helixin C;Polyetherin A;尼日利亚菌素钠盐;尼日利亚菌素钠

溶解度

DMSO	Insoluble
Water	Insoluble
Ethanol	100.0 mg/mL (133.9 mM)

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Nigericin sodium salt/尼日利亚菌素钠盐 Catalog No. CSN11558

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