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CAS No.: 51803-78-2

Nimesulide/尼美舒利 Catalog No. CSN11614

Synonyms: R805;Flogovital;尼美舒利

Nimesulide is a COX2 selective inhibitor with IC50 of 26 μM.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties^[3]. Nimesulide, but not indomethacin, reduced the fever induced by MIP-1alpha, PGF(2alpha), CRF or ET-1. Plasma TNF-alpha levels in LPS-treated rats were also reduced by nimesulide^[4]. Nimesulide (10 µM) effectively decreases VEGF in endometrium cancer cells, and shows no effect on that in normal cells. Nimesulide (10 and 50 µM) dramatically decreases MCP-1 levels in normal cell, and such an effect is also observed with 10 µM in cancer cells. In addition, Nimesulide (50 µM) potently affects IL-8 level in normal cells, but causes no changes in cancer cells^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02466581	Rheumatoid Arthritis	Phase 4	Recruiting	December 2021	Sweden ... more >> Karolinska Institutet Recruiting Stockholm, Sweden, 171 76 Contact: Ronald van Vollenhoven, MD, prof +46(8)51776077 ronald.van.vollenhoven@ki.se Contact: Monica Ryden Aulin, PhD +46(8)51771110 monica.ryden.aulin@ki.se Collapse <<
NCT02563756	Knee Osteoarthritis	Not Applicable	Recruiting	September 2022	Sweden ... more >> Karolinska University Hospital Recruiting Stockholm, Sweden Contact: Carl Aulin, MD carl.aulin@karolinska.se Contact: Nicolas Martinez, MD +46709900089 nicolas.martinez-carranza@karolinska.se Collapse <<
NCT03104985	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2435 mL
- 16.2175 mL
- 32.4349 mL
- 5 mM
- 0.6487 mL
- 3.2435 mL
- 6.4870 mL
- 10 mM
- 0.3243 mL
- 1.6217 mL
- 3.2435 mL

技术信息

CAS号

51803-78-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H12N2O5S

运输

蓝冰

分子量

308.31

别名

R805;Flogovital;尼美舒利

溶解度

DMSO	60.0 mg/mL (194.6 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02466581	Rheumatoid Arthritis	Phase 4	Recruiting	December 2021	Sweden ... more >> Karolinska Institutet Recruiting Stockholm, Sweden, 171 76 Contact: Ronald van Vollenhoven, MD, prof +46(8)51776077 ronald.van.vollenhoven@ki.se Contact: Monica Ryden Aulin, PhD +46(8)51771110 monica.ryden.aulin@ki.se Collapse <<
NCT02563756	Knee Osteoarthritis	Not Applicable	Recruiting	September 2022	Sweden ... more >> Karolinska University Hospital Recruiting Stockholm, Sweden Contact: Carl Aulin, MD carl.aulin@karolinska.se Contact: Nicolas Martinez, MD +46709900089 nicolas.martinez-carranza@karolinska.se Collapse <<
NCT03104985	-	-	Completed	-	-
NCT02575274	Peri-implantitis	Phase 2 Phase 3	Unknown	July 2016	Brazil ... more >> Federal University of Minas Gerais Belo Horizonte, Minas Gerais, Brazil, 30110031 Collapse <<
NCT03400462	Temporomandibular Disorder	Not Applicable	Completed	-	-
NCT03104985	Trophic Ulcers ... more >> Chronic Venous Insufficiency Collapse <<	Not Applicable	Completed	-	Russian Federation ... more >> Tula Municipal Clinical Hospital №2 Tula, Russian Federation, 300002 Collapse <<
NCT03616574	Advanced or Metastatic Solid T... more >>umors Advanced or Metastatic Colorectal Cancer (mCRC) Collapse <<	Phase 1	Not yet recruiting	June 2021	-
NCT00932542	Hemorrhoidectomy	Phase 2 Phase 3	Unknown	November 2012	Brazil ... more >> Clínica Reis Neto Campinas, São Paulo, Brazil, 13010-112 Collapse <<
NCT03119324	Temporomandibular Joint Disord... more >>ers Collapse <<	Not Applicable	Completed	-	-
NCT01670552	Acute and Chronic Inflammation... more >> Dyspepsia Collapse <<	Phase 3	Unknown	April 2017	Brazil ... more >> Allegisa Recruiting Campinas, São Paulo, Brazil, 13.084-791 Contact: Pedro A. Petersen, MD +5519 3789-8610 alexandra@grupoinvestiga.com.br Contact: Alexandra F. Drumont, SC +5519 3789-8610 alexandra@grupoinvestiga.com.br Collapse <<
NCT01500577	Breast Cancer	Phase 2	Completed	-	Italy ... more >> European Institute of Oncology Milan, Italy Collapse <<
NCT02922712	Knee Osteoarthritis	Phase 4	Completed	-	-
NCT01745614	Pain	Phase 1	Completed	-	-
NCT01306708	Adhesive Capsulitis	Phase 2	Completed	-	Brazil ... more >> Universidade do Sul de Santa Catarina Tubarão, Santa Catarina, Brazil, 88704-900 Collapse <<
NCT02229747	Pharyngitis	Phase 4	Completed	-	-
NCT01257126	Upper Respiratory Tract Infect... more >>ions Collapse <<	Phase 4	Withdrawn	-	-
NCT01609205	Rheumatoid Arthritis	Phase 4	Completed	-	Sweden ... more >> Linköping University Hospital Linköping, Sweden The karolinska Institute Stockholm, Sweden, 171 76 Collapse <<

Nimesulide/尼美舒利 Catalog No. CSN11614

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