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CAS No.: 132819-92-2

NOD-IN-1 Catalog No. CSN18850

Synonyms: MDK19922;compound 4

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

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技术信息

生物活性

描述NOD1 and NOD2 are important members of the pattern recognition receptor family and play a crucial role within the context of innate immunity. However, overactivation of NODs, especially of NOD1, has also been implicated in a number of diseases^[2]. NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC₅₀ values of 5.74 μM and 6.45 μM, respectively, displaying a balanced inhibitory activity on both targets in the low micromolar range^[2]. NOD-IN-1 was identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1^[2].
参考文献

[1] Kecek Plešec K, Urbancic D, et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234.
[2] Keček Plešec K, Urbančič D, Gobec M, Pekošak A, Tomašič T, Anderluh M, Mlinarič-Raščan I, Jakopin Ž. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234. doi: 10.1016/j.bmc.2016.08.044. Epub 2016 Aug 24. PMID: 27601373.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9121 mL
- 14.5603 mL
- 29.1206 mL
- 5 mM
- 0.5824 mL
- 2.9121 mL
- 5.8241 mL
- 10 mM
- 0.2912 mL
- 1.4560 mL
- 2.9121 mL

技术信息

CAS号

132819-92-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H17NO4S

运输

蓝冰

分子量

343.40

别名

MDK19922;compound 4

溶解度

DMSO	53.33 mg/mL (155.3 mM)
Water	insoluble

动物实验配方

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