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CAS No.: 81624-55-7

NSC348884 Catalog No. CSN17239

Synonyms: NSC 348884

NSC348884 is a nucleophosmin (NPM) inhibitor, inhibits cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.

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技术信息

生物活性

描述Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, and ribonucleic cleavage. NSC 348884 is a nucleophosmin inhibitor that interferes with the oligomer formation of nucleophosmin. In LNCaP and HCT116 cells, treatment with NSC 348884 at 5 or 6μM for 24 h disrupted the dimerization of nucleophosmin. NSC 348884 inhibited the proliferation of LNCaP and Granta cells with IC50 values of ~4μM and ~1.7μM, respectively. Treatment with NSC 348884 at 0–5μM dose-dependently increased apoptotic cell death in LNCaP cells. LNCaP cells treated with NSC 348884 (0-5μM) also showed upregulated p53 expression and Ser15 phosphorylation after 2h of treatment.^[3] In mice bearing either MDA-MB-231 tumors or patient-derived HT17 and HT39 tumors, intraperitoneal injection of NSC 348884 (25mg/kg) significantly inhibited in vivo invasion and intravasation compared to vehicle-treated controls.^[4]
作用机制NSC 348884 inhibits nucleophosmin by binding to its dimer interface and disrupting oligomer formation.^[3]
参考文献

[1] Patsialou A, Wang Y, et al. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res. 2012 Oct 31;14(5):R139.
[2] Qi W, Shakalya K, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008 Jul 10;27(30):4210-20.
[3] Qi W, Shakalya K, Stejskal A, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene. 2008;27(30):4210-4220. doi:10.1038/onc.2008.54
[4] Patsialou A, Wang Y, Lin J, et al. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res. 2012;14(5):R139. Published 2012 Oct 31. doi:10.1186/bcr3344

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5704 mL
- 7.8519 mL
- 15.7037 mL
- 5 mM
- 0.3141 mL
- 1.5704 mL
- 3.1407 mL
- 10 mM
- 0.1570 mL
- 0.7852 mL
- 1.5704 mL

技术信息

CAS号

81624-55-7

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C38H40N10

运输

蓝冰

分子量

636.79

别名

NSC 348884

溶解度

DMSO	50.0 mg/mL (78.5 mM)
Water	insoluble

动物实验配方

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