|6-(环己基甲氧基)-5-亚硝基嘧啶-2,4-二胺|CsnPharm

CAS No.: 220036-08-8

NU6027 Catalog No. CSN19184

Synonyms: Nu6027

NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.

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描述Cyclin-dependent kinases (CDKs) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function^[3]. NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner^[4]. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1^[5]. NU6027 prevented the Trovafloxacin-mediated increases in LPS-induced TNF mRNA and protein release, Trovafloxacin prolonged TNF mRNA stability, and this effect was largely attenuated by NU6027^[6]. NU-6027 inhibits Mycobacterium bovis BCG growth in vitro and also displayed cross-reactivity with Mycobacterium tuberculosis protein kinase D (PknD) and protein kinase G (PknG)^[7].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9795 mL
- 19.8973 mL
- 39.7947 mL
- 5 mM
- 0.7959 mL
- 3.9795 mL
- 7.9589 mL
- 10 mM
- 0.3979 mL
- 1.9897 mL
- 3.9795 mL

技术信息

CAS号	220036-08-8	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C11H17N5O2	运输	蓝冰
分子量	251.29	别名	Nu6027

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