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CAS No.: 675576-98-4
Synonyms: Rebemadlin;Nutlin-3a Chiral;(-)-Nutlin 3
Nutlin 3a is an improved MDM2-p53 interation antagonist thus acting as p53 (TP53) activator and stabilizer. It is a more potent diastereoisomer of Nutlin-3.
生物活性
实验方案
技术信息
CAS号 | 675576-98-4 | 储存条件 |
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分子式 | C30H30Cl2N4O4 | 运输 | 蓝冰 | |||||||||||
分子量 | 581.49 | 别名 | Rebemadlin;Nutlin-3a Chiral;(-)-Nutlin 3;(−)-Nutlin-3;SML-0580 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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22RV1 | - | Growth Inhibition Assay | - | IC50=12.8059 μM | SANGER |
697 | - | Growth Inhibition Assay | - | IC50=5.4455 μM | SANGER |
A101D | - | Growth Inhibition Assay | - | IC50=2.3501 μM | SANGER |
A172 | - | Growth Inhibition Assay | - | IC50=2.67588 μM | SANGER |
A204 | - | Growth Inhibition Assay | - | IC50=3.05588 μM | SANGER |
A375 | - | Growth Inhibition Assay | - | IC50=4.33524 μM | SANGER |
A3-KAW | - | Growth Inhibition Assay | - | IC50=2.61818 μM | SANGER |
A427 | - | Growth Inhibition Assay | - | IC50=6.87829 μM | SANGER |
A549 | - | Growth Inhibition Assay | - | IC50=3.63552 μM | SANGER |
AGS | - | Growth Inhibition Assay | - | IC50=6.14828 μM | SANGER |
AM-38 | - | Growth Inhibition Assay | - | IC50=6.75639 μM | SANGER |
AsPC-1 | - | Growth Inhibition Assay | - | IC50=36.1527 μM | SANGER |
BE-13 | - | Growth Inhibition Assay | - | IC50=35.6545 μM | SANGER |
BEN | - | Growth Inhibition Assay | - | IC50=16.5638 μM | SANGER |
BHT-101 | - | Growth Inhibition Assay | - | IC50=19.8705 μM | SANGER |
BV-173 | - | Growth Inhibition Assay | - | IC50=2.84439 μM | SANGER |
C2BBe1 | - | Growth Inhibition Assay | - | IC50=3.17026 μM | SANGER |
C32 | - | Growth Inhibition Assay | - | IC50=5.60029 μM | SANGER |
CAKI-1 | - | Growth Inhibition Assay | - | IC50=3.12694 μM | SANGER |
CAL-27 | - | Growth Inhibition Assay | - | IC50=37.7231 μM | SANGER |
CAL-51 | - | Growth Inhibition Assay | - | IC50=9.10251 μM | SANGER |
CAL-54 | - | Growth Inhibition Assay | - | IC50=4.53019 μM | SANGER |
CHP-134 | - | Growth Inhibition Assay | - | IC50=2.93882 μM | SANGER |
CHP-212 | - | Growth Inhibition Assay | - | IC50=1.81369 μM | SANGER |
COLO-678 | - | Growth Inhibition Assay | - | IC50=9.32811 μM | SANGER |
COLO-679 | - | Growth Inhibition Assay | - | IC50=15.501 μM | SANGER |
COLO-829 | - | Growth Inhibition Assay | - | IC50=7.24188 μM | SANGER |
COR-L105 | - | Growth Inhibition Assay | - | IC50=46.8857 μM | SANGER |
CP50-MEL-B | - | Growth Inhibition Assay | - | IC50=4.24392 μM | SANGER |
CTB-1 | - | Growth Inhibition Assay | - | IC50=2.02246 μM | SANGER |
CTV-1 | - | Growth Inhibition Assay | - | IC50=4.07973 μM | SANGER |
D-247MG | - | Growth Inhibition Assay | - | IC50=4.75072 μM | SANGER |
D-283MED | - | Growth Inhibition Assay | - | IC50=3.57986 μM | SANGER |
D-392MG | - | Growth Inhibition Assay | - | IC50=8.52722 μM | SANGER |
D-502MG | - | Growth Inhibition Assay | - | IC50=2.97154 μM | SANGER |
DB | - | Growth Inhibition Assay | - | IC50=21.5649 μM | SANGER |
DBTRG-05MG | - | Growth Inhibition Assay | - | IC50=26.6488 μM | SANGER |
DEL | - | Growth Inhibition Assay | - | IC50=48.0429 μM | SANGER |
DK-MG | - | Growth Inhibition Assay | - | IC50=2.62471 μM | SANGER |
DOHH-2 | - | Growth Inhibition Assay | - | IC50=2.42279 μM | SANGER |
DU-4475 | - | Growth Inhibition Assay | - | IC50=2.79502 μM | SANGER |
EFO-21 | - | Growth Inhibition Assay | - | IC50=40.5814 μM | SANGER |
EoL-1-cell | - | Growth Inhibition Assay | - | IC50=1.26701 μM | SANGER |
ES3 | - | Growth Inhibition Assay | - | IC50=14.6562 μM | SANGER |
ES4 | - | Growth Inhibition Assay | - | IC50=2.43155 μM | SANGER |
EW-16 | - | Growth Inhibition Assay | - | IC50=46.3137 μM | SANGER |
EW-3 | - | Growth Inhibition Assay | - | IC50=14.1639 μM | SANGER |
G-401 | - | Growth Inhibition Assay | - | IC50=3.36322 μM | SANGER |
G-402 | - | Growth Inhibition Assay | - | IC50=3.80832 μM | SANGER |
GAK | - | Growth Inhibition Assay | - | IC50=35.695 μM | SANGER |
GI-ME-N | - | Growth Inhibition Assay | - | IC50=6.22421 μM | SANGER |
GOTO | - | Growth Inhibition Assay | - | IC50=3.84333 μM | SANGER |
GP5d | - | Growth Inhibition Assay | - | IC50=15.1466 μM | SANGER |
GR-ST | - | Growth Inhibition Assay | - | IC50=32.4453 μM | SANGER |
H4 | - | Growth Inhibition Assay | - | IC50=0.6628 μM | SANGER |
H9 | - | Growth Inhibition Assay | - | IC50=31.3008 μM | SANGER |
HAL-01 | - | Growth Inhibition Assay | - | IC50=16.8909 μM | SANGER |
HCC1954 | - | Growth Inhibition Assay | - | IC50=24.8844 μM | SANGER |
HCC2218 | - | Growth Inhibition Assay | - | IC50=7.6297 μM | SANGER |
HCT-116 | - | Growth Inhibition Assay | - | IC50=3.30335 μM | SANGER |
HDLM-2 | - | Growth Inhibition Assay | - | IC50=36.316 μM | SANGER |
H-EMC-SS | - | Growth Inhibition Assay | - | IC50=6.386 μM | SANGER |
HL-60 | - | Growth Inhibition Assay | - | IC50=16.0384 μM | SANGER |
HMV-II | - | Growth Inhibition Assay | - | IC50=15.3333 μM | SANGER |
HT-1080 | - | Growth Inhibition Assay | - | IC50=7.48254 μM | SANGER |
HT-1197 | - | Growth Inhibition Assay | - | IC50=16.0352 μM | SANGER |
HT-144 | - | Growth Inhibition Assay | - | IC50=2.64577 μM | SANGER |
IGR-1 | - | Growth Inhibition Assay | - | IC50=14.0347 μM | SANGER |
IGROV-1 | - | Growth Inhibition Assay | - | IC50=12.6573 μM | SANGER |
IST-MES1 | - | Growth Inhibition Assay | - | IC50=4.41411 μM | SANGER |
JAR | - | Growth Inhibition Assay | - | IC50=15.7205 μM | SANGER |
JEG-3 | - | Growth Inhibition Assay | - | IC50=14.4953 μM | SANGER |
JVM-2 | - | Growth Inhibition Assay | - | IC50=48.0558 μM | SANGER |
JVM-3 | - | Growth Inhibition Assay | - | IC50=2.59324 μM | SANGER |
K5 | - | Growth Inhibition Assay | - | IC50=1.42072 μM | SANGER |
KARPAS-45 | - | Growth Inhibition Assay | - | IC50=49.4538 μM | SANGER |
KG-1 | - | Growth Inhibition Assay | - | IC50=23.4946 μM | SANGER |
KGN | - | Growth Inhibition Assay | - | IC50=3.08496 μM | SANGER |
KM-H2 | - | Growth Inhibition Assay | - | IC50=7.88694 μM | SANGER |
KNS-81-FD | - | Growth Inhibition Assay | - | IC50=6.76494 μM | SANGER |
KS-1 | - | Growth Inhibition Assay | - | IC50=3.01623 μM | SANGER |
KYSE-450 | - | Growth Inhibition Assay | - | IC50=34.6776 μM | SANGER |
LAMA-84 | - | Growth Inhibition Assay | - | IC50=34.6073 μM | SANGER |
LAN-6 | - | Growth Inhibition Assay | - | IC50=11.9928 μM | SANGER |
LB2241-RCC | - | Growth Inhibition Assay | - | IC50=3.65708 μM | SANGER |
LB2518-MEL | - | Growth Inhibition Assay | - | IC50=33.0797 μM | SANGER |
LB996-RCC | - | Growth Inhibition Assay | - | IC50=3.62558 μM | SANGER |
LNCaP-Clone-FGC | - | Growth Inhibition Assay | - | IC50=2.64318 μM | SANGER |
LoVo | - | Growth Inhibition Assay | - | IC50=6.01624 μM | SANGER |
LOXIMVI | - | Growth Inhibition Assay | - | IC50=3.85675 μM | SANGER |
LS-513 | - | Growth Inhibition Assay | - | IC50=6.79026 μM | SANGER |
LU-99A | - | Growth Inhibition Assay | - | IC50=35.0007 μM | SANGER |
LXF-289 | - | Growth Inhibition Assay | - | IC50=23.714 μM | SANGER |
MCF7 | - | Growth Inhibition Assay | - | IC50=5.44244 μM | SANGER |
MDA-MB-175-VII | - | Growth Inhibition Assay | - | IC50=14.7111 μM | SANGER |
MEL-HO | - | Growth Inhibition Assay | - | IC50=5.85667 μM | SANGER |
MHH-NB-11 | - | Growth Inhibition Assay | - | IC50=3.26827 μM | SANGER |
MKN45 | - | Growth Inhibition Assay | - | IC50=8.26602 μM | SANGER |
ML-2 | - | Growth Inhibition Assay | - | IC50=2.56576 μM | SANGER |
MMAC-SF | - | Growth Inhibition Assay | - | IC50=10.3961 μM | SANGER |
MN-60 | - | Growth Inhibition Assay | - | IC50=3.44092 μM | SANGER |
MOLT-16 | - | Growth Inhibition Assay | - | IC50=1.78604 μM | SANGER |
MOLT-4 | - | Growth Inhibition Assay | - | IC50=2.32853 μM | SANGER |
Mo-T | - | Growth Inhibition Assay | - | IC50=32.5046 μM | SANGER |
MSTO-211H | - | Growth Inhibition Assay | - | IC50=2.57451 μM | SANGER |
MV-4-11 | - | Growth Inhibition Assay | - | IC50=0.61237 μM | SANGER |
MZ2-MEL | - | Growth Inhibition Assay | - | IC50=4.50155 μM | SANGER |
NB10 | - | Growth Inhibition Assay | - | IC50=3.20966 μM | SANGER |
NB12 | - | Growth Inhibition Assay | - | IC50=11.503 μM | SANGER |
NB17 | - | Growth Inhibition Assay | - | IC50=4.31768 μM | SANGER |
NB5 | - | Growth Inhibition Assay | - | IC50=6.56183 μM | SANGER |
NB69 | - | Growth Inhibition Assay | - | IC50=2.65334 μM | SANGER |
NCI-H1563 | - | Growth Inhibition Assay | - | IC50=13.4202 μM | SANGER |
NCI-H1573 | - | Growth Inhibition Assay | - | IC50=35.8818 μM | SANGER |
NCI-H1650 | - | Growth Inhibition Assay | - | IC50=7.39228 μM | SANGER |
NCI-H1666 | - | Growth Inhibition Assay | - | IC50=15.9399 μM | SANGER |
NCI-H2052 | - | Growth Inhibition Assay | - | IC50=27.5684 μM | SANGER |
NCI-H2087 | - | Growth Inhibition Assay | - | IC50=45.0233 μM | SANGER |
NCI-H2122 | - | Growth Inhibition Assay | - | IC50=6.58793 μM | SANGER |
NCI-H226 | - | Growth Inhibition Assay | - | IC50=8.21122 μM | SANGER |
NCI-H28 | - | Growth Inhibition Assay | - | IC50=4.62717 μM | SANGER |
NCI-H292 | - | Growth Inhibition Assay | - | IC50=3.12028 μM | SANGER |
NCI-H358 | - | Growth Inhibition Assay | - | IC50=7.44879 μM | SANGER |
NCI-H441 | - | Growth Inhibition Assay | - | IC50=37.0691 μM | SANGER |
NCI-H460 | - | Growth Inhibition Assay | - | IC50=4.91127 μM | SANGER |
NCI-H661 | - | Growth Inhibition Assay | - | IC50=7.87069 μM | SANGER |
NCI-H720 | - | Growth Inhibition Assay | - | IC50=15.9989 μM | SANGER |
NCI-H747 | - | Growth Inhibition Assay | - | IC50=22.7379 μM | SANGER |
NCI-H82 | - | Growth Inhibition Assay | - | IC50=33.1661 μM | SANGER |
NCI-SNU-1 | - | Growth Inhibition Assay | - | IC50=3.27843 μM | SANGER |
NEC8 | - | Growth Inhibition Assay | - | IC50=1.21572 μM | SANGER |
NH-12 | - | Growth Inhibition Assay | - | IC50=4.01959 μM | SANGER |
NKM-1 | - | Growth Inhibition Assay | - | IC50=1.04931 μM | SANGER |
NMC-G1 | - | Growth Inhibition Assay | - | IC50=12.4175 μM | SANGER |
NTERA-S-cl-D1 | - | Growth Inhibition Assay | - | IC50=10.6508 μM | SANGER |
ONS-76 | - | Growth Inhibition Assay | - | IC50=5.57009 μM | SANGER |
OS-RC-2 | - | Growth Inhibition Assay | - | IC50=5.73887 μM | SANGER |
OVCAR-3 | - | Growth Inhibition Assay | - | IC50=39.3181 μM | SANGER |
P30-OHK | - | Growth Inhibition Assay | - | IC50=15.0496 μM | SANGER |
PA-1 | - | Growth Inhibition Assay | - | IC50=0.87096 μM | SANGER |
QIMR-WIL | - | Growth Inhibition Assay | - | IC50=1.60854 μM | SANGER |
Ramos-2G6-4C10 | - | Growth Inhibition Assay | - | IC50=26.4981 μM | SANGER |
RCC10RGB | - | Growth Inhibition Assay | - | IC50=8.86695 μM | SANGER |
RH-18 | - | Growth Inhibition Assay | - | IC50=4.27706 μM | SANGER |
RKO | - | Growth Inhibition Assay | - | IC50=3.53936 μM | SANGER |
RMG-I | - | Growth Inhibition Assay | - | IC50=29.4139 μM | SANGER |
RPMI-2650 | - | Growth Inhibition Assay | - | IC50=7.94414 μM | SANGER |
RPMI-8226 | - | Growth Inhibition Assay | - | IC50=39.598 μM | SANGER |
RPMI-8866 | - | Growth Inhibition Assay | - | IC50=2.56214 μM | SANGER |
RS4-11 | - | Growth Inhibition Assay | - | IC50=2.72407 μM | SANGER |
RVH-421 | - | Growth Inhibition Assay | - | IC50=6.42428 μM | SANGER |
SBC-1 | - | Growth Inhibition Assay | - | IC50=17.5429 μM | SANGER |
SH-4 | - | Growth Inhibition Assay | - | IC50=17.5841 μM | SANGER |
SHP-77 | - | Growth Inhibition Assay | - | IC50=12.5574 μM | SANGER |
SJSA-1 | - | Growth Inhibition Assay | - | IC50=2.82556 μM | SANGER |
SK-HEP-1 | - | Growth Inhibition Assay | - | IC50=3.74297 μM | SANGER |
SK-LU-1 | - | Growth Inhibition Assay | - | IC50=23.3524 μM | SANGER |
SK-MEL-1 | - | Growth Inhibition Assay | - | IC50=21.5872 μM | SANGER |
SK-MEL-24 | - | Growth Inhibition Assay | - | IC50=9.55856 μM | SANGER |
SK-MEL-3 | - | Growth Inhibition Assay | - | IC50=13.3973 μM | SANGER |
SK-MEL-30 | - | Growth Inhibition Assay | - | IC50=9.94476 μM | SANGER |
SK-N-AS | - | Growth Inhibition Assay | - | IC50=46.7167 μM | SANGER |
SNU-C2B | - | Growth Inhibition Assay | - | IC50=41.5084 μM | SANGER |
SW1088 | - | Growth Inhibition Assay | - | IC50=32.9801 μM | SANGER |
SW1573 | - | Growth Inhibition Assay | - | IC50=12.3086 μM | SANGER |
SW48 | - | Growth Inhibition Assay | - | IC50=15.9516 μM | SANGER |
SW780 | - | Growth Inhibition Assay | - | IC50=2.50883 μM | SANGER |
SW900 | - | Growth Inhibition Assay | - | IC50=16.9132 μM | SANGER |
SW954 | - | Growth Inhibition Assay | - | IC50=6.55572 μM | SANGER |
SW982 | - | Growth Inhibition Assay | - | IC50=3.50848 μM | SANGER |
U-2-OS | - | Growth Inhibition Assay | - | IC50=2.9107 μM | SANGER |
UACC-257 | - | Growth Inhibition Assay | - | IC50=11.8695 μM | SANGER |
UACC-62 | - | Growth Inhibition Assay | - | IC50=17.7637 μM | SANGER |
VA-ES-BJ | - | Growth Inhibition Assay | - | IC50=2.5411 μM | SANGER |
VM-CUB-1 | - | Growth Inhibition Assay | - | IC50=43.8037 μM | SANGER |
WM-115 | - | Growth Inhibition Assay | - | IC50=6.9323 μM | SANGER |
靶点 | Description | IC50 |
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