|3-(2-(4-(6-氟苯并[d]异恶唑-3-基)哌啶-1-基)乙基)-2,9-二甲基-4H-吡啶并[1,2-a]嘧啶-4-酮|CsnPharm

CAS No.: 129029-23-8

Synonyms: R79598;R-79,598

Ocaperidone is a benzisoxazole is an antagonist of both 5HT and D2 receptors.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述Schizophrenia and most neuropsychiatric disorders have reciprocal connections with metabolic disturbances^[3]. Ocaperidone is a new benzisoxazol antipsychotic with particularly beneficial effects in schizophrenia. Ocaperidone acts as a potent 5-HT₂ and dopamine D₂ antagonist with K_i values of 0.14 and 0.75 nM, respectively^[4]. Ocaperidone inhibited dopamine agonist (apomorphine, amphetamine or cocaine)-induced behavioral effects at low doses (0.014-0.042 mg/kg). Ocaperidone completely blocked the dopamine agonist behavior at slightly higher doses (0.064 mg/kg). Ocaperidone also antagonized serotonin agonist (tryptamine, mescaline or 5-hydroxytryptophan)-induced behavioral effects (0.011-0.064 mg/kg)^[5]. In vivo binding in rats, using intravenous administration of [³H]spiperone, revealed very potent occupation by ocaperidone and risperidone of 5HT₂ receptors in the frontal cortex (ED₅₀ of 0.04-0.03 mg/kg)^[4]. In the apomorphine test in dogs, ocaperidone was very potent (i.v., s.c. and p.o. ED50 values: less than 1.0 micrograms/kg) and showed a rapid onset (less than 0.5 h) and long duration of action (24 h) after p.o. administration^[5].
参考文献

实验方案

技术信息

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户