生物活性

• 描述OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor with Kd values of 100 nM/500 nM for BRPF1B/BRPF2, showing 39-fold selectivity over BRD4.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03301311	Inflammatory Bowel Diseases ... more >> Crohn Disease Ulcerative Colitis Collapse <<	Not Applicable	Recruiting	December 2, 2019	United States, California ... more >> Lucile Packard Children's Hospital Recruiting Palo Alto, California, United States, 94304 Contact: Jennifer Burgis, MD          University of California San Francisco Benioff Children's Hospita; Recruiting San Francisco, California, United States, 94158 Contact: Mel Heyman, MD          United States, Delaware Nemours, Alfred I duPont Hospital for Children Recruiting Wilmington, Delaware, United States, 19803 Contact: Zarela Molle Rios, MD          United States, Georgia GI Care for Kids Recruiting Atlanta, Georgia, United States, 30342 Contact: Ben Gold, MD          Contact: Stanley Cohen, MD          United States, Indiana Riley Hospital for Children Recruiting Indianapolis, Indiana, United States, 46202 Contact: Steven Steiner, MD          United States, Missouri Children's Mercy Hospital Recruiting Kansas City, Missouri, United States, 64108 Contact: Alka Goyal, MD          United States, Ohio Nationwide Children's Hospital Not yet recruiting Columbus, Ohio, United States, 43205 Contact: Brendan Boyle, MD          United States, Oregon Oregon Health Sciences University Not yet recruiting Portland, Oregon, United States, 97239 Contact: Mikelle Bassett, MD          Contact: Beata Dyar          United States, Texas UT Soutwestern Medical Center Recruiting Dallas, Texas, United States, 75235 Contact: Ashish Patel, MD          United States, Virginia Pediatric Specialists of Virginia Recruiting Fairfax, Virginia, United States, 22031 Contact: Peter Lee, MD          Children's Hospital of the King's Daughters Recruiting Norfolk, Virginia, United States, 23507 Contact: Nancy Yakois, MD          United States, Washington Seattle Children's Recruiting Seattle, Washington, United States, 98105 Contact: Dale Lee, MD Collapse <<
  NCT01710007	Hypercholesterolemia	Phase 3	Completed	-	Taiwan ... more >> Buddhist Taipei TzuChi General Hospital New Taipei City, Taiwan, 23142 Cardinal Tien Hospital New Taipei City, Taiwan, 231 Taipei Medical University - Shuang Ho Hospital New Taipei City, Taiwan, 23561 Taichung Veterans General Hospital Taichung City, Taiwan, 40705 Taipei Veterans General Hospital Taipei City, Taiwan, 11217 Cheng Hsin General Hospital Taipei City, Taiwan, 112 Tri-Service General Hospital Taipei City, Taiwan, 114 Chang Gung Medical Foundation- LinKuo Branch Taoyuan City, Taiwan, 333 Collapse <<
  NCT02142621	Bronchopulmonary Dysplasia	Not Applicable	Completed	-	United States, Pennsylvania ... more >> The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Collapse <<

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