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CAS No.: 1357302-64-7

OG-L002 Catalog No. CSN17182

Synonyms: OG-L002

OG-L002 is a selective inhibitor of LSD1 with IC50 of 20 nM.

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实验方案

技术信息

生物活性

描述The histone H3K9 demethylase LSD1 plays a critical role in the regulation of herpes simplex virus (HSV) infection. OG-L002 is a selective inhibitor of LSD1 with an IC50 value of 0.02μM. It is also a potent inhibitor of monoamine oxidases (MAO) with IC50 values of 1.38μM and 0.72μM for MAO-A and MAO-B, respectively. OG-L002 inhibited viral immediate-early gene expression in HeLa and HFF cells with IC50 values of ~10µM and ~3µM, respectively. Treatment of Hela cells with 50µM OG-L002 for 24 hours reduced viral yields compared with the DMSO-treated controls. Also in Hela cells, pretreatment with 50µM OG-L002 for 4 hours increased the levels of total histone H3 and H3K9-me2 (20- to 30-fold) associated with viral immediate-early gene promoters. Treatment with OG-L002 (10 - 50µM) for 48 hours repressed viral reactivation in trigeminal ganglia isolated from HSV-infected mice. In BALB/c mice, pretreatment with OG-L002 (6 - 40mg/kg/day) for one week reduced the levels of detectable viral genomes in the ganglia at both 3- and 5-day post-infection. The administration of mice with OG-L002 at a dose of 20mg/kg/day reduced viral genome accumulation at 3-, 5-, and 10-day post-infection^[2].
作用机制OG-L002 is a potent LSD1 inhibitor that blocks HSV lytic replication and reactivation from latency^[2].
参考文献

[1] Liang Y, Quenelle D, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 2013 Feb 5;4(1):e00558-12.
[2] Liang Y, Quenelle D, Vogel JL, Mascaro C, Ortega A, Kristie TM. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4388 mL
- 22.1940 mL
- 44.3881 mL
- 5 mM
- 0.8878 mL
- 4.4388 mL
- 8.8776 mL
- 10 mM
- 0.4439 mL
- 2.2194 mL
- 4.4388 mL

技术信息

CAS号

1357302-64-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H15NO

运输

蓝冰

分子量

225.29

别名

OG-L002

溶解度

DMSO	285.0 mg/mL (1265.1 mM)
Water	insoluble

动物实验配方

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