生物活性

• 描述Oglufanide (H-Glu-Trp-OH; L-Glutamyl-L-tryptophan) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections^[2]. Oglufanide effect on survival and spontaneous tumor incidence was studied in female LIO rats. Rats were injected with Oglufanide dissolved in normal saline subcutaneously in a single daily dose 5 µg/animal for 5 consecutive days weekly, during 12 months, starting at the age of 5 months. Mean life span of rats in Oglufanide and control groups was similar but that of 10% maximum survived control rats constituted 949 ± 16.1 days, whereas in the dipeptide-treated rats this value was 1048 ± 21.1 days (P < 0.001). Total tumor incidence was 1.5 times lower (P < 0.01), malignant tumor incidence 1.7 times lower (P < 0.01), and hematopoietic malignancies (leukemias and lymphomas) 3.4 times lower (P < 0.02) in rats exposed to the dipeptide in comparison with controlsAnisimov VN, Khavinson VK, Morozov VG. Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats. Biogerontology. 2000;1(1):55-9..
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00017303	Ovarian Cancer ... more >> Primary Peritoneal Cavity Cancer Collapse <<	Phase 2	Unknown	-	United States, California ... more >> Comprehensive Cancer Center Glendale, California, United States, 91204 Community Hospital of Los Gatos Los Gatos, California, United States, 95032 Stanford University Medical Center Stanford, California, United States, 94305-5408 United States, District of Columbia Lombardi Cancer Center Washington, District of Columbia, United States, 20007 United States, Georgia Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas School of Medicine-Wichita Wichita, Kansas, United States, 67214 United States, Minnesota University of Minnesota Cancer Center Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198-3330 United States, Nevada Women's Cancer Center - Las Vegas Las Vegas, Nevada, United States, 89030 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 United States, North Carolina Lineberger Comprehensive Cancer Center, UNC Chapel Hill, North Carolina, United States, 27599-7295 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210-1240 United States, Pennsylvania Magee-Womens Hospital Pittsburgh, Pennsylvania, United States, 15213-3180 United States, Vermont Fletcher Allen Health Care - Medical Center Campus Burlington, Vermont, United States, 05401 United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109-1024 University of Washington School of Medicine Seattle, Washington, United States, 98195 United States, Wisconsin University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin, United States, 53792-6164 Collapse <<
  NCT00006037	Colorectal Cancer	Phase 2	Terminated(Drug not available)	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90033-0804 Collapse <<
  NCT00003773	Ovarian Cancer	Phase 1	Completed	-	United States, California ... more >> USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033-0800 Collapse <<

• 参考文献

• [1] Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61.

  [2] Kaushik NK, Kaushik N, Attri P, Kumar N, Kim CH, Verma AK, Choi EH. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62