|(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-乙基-7,11,14,15-四羟基-6'-((R)-2-羟基丙基)-5',6,8,10,12,14,16,28,29-九甲基-3',4',5',6'-四氢-2,26二氧杂螺[双环[23.3.1]二十九烷[4,18,20]三烯-27,2'-吡喃]-3,9,13-三酮|CsnPharm

CAS No.: 579-13-5

Oligomycin A/寡霉素A Catalog No. CSN15998

Synonyms: MCH 32;寡霉素A

Oligomycin A, a mitochondrial ATP synthase inhibitor, is isolated from Streptomyces species, exhibits anti-tumor and antibiotic activity.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Oligomycin is a macrolide antibiotic, usually used as a potent inhibitor of mitochondrial F0F1-ATPase and oxidative phosphorylation, with Ki value of 1μM for inhibition of yeast intact mitochondrial ATPase activity and 0.1μM for Triton X-100-solubilized mitochondria^[1]. Oligomycin at concentration of 1.5-3μM stimulated lysosome acidification due to shunting of membrane potential^[2]. Treatment with 2.5μM oligomycin dramatically reduced ATP level in MII oocytes exposure to H₂O₂^[3]. Oligomycin A exhibited antiproliferative effect on the JARID1B^high subpopulation of WM3734 cells at concentration ranging in 0.1-10μg/ml post 24-72h due to the inhibition of mitochondrial respiration^[4].
作用机制Oligomycin could bind to the c10 ring of the of the yeast mitochondrial ATP synthase thereby making contact with two neighboring molecules at a position. The carboxyl side chain of Glu59, which is essential for proton translocation, forms an H-bond with oligomycin.^[5]
动物研究
剂量
Mice: 0.1 mg/kg^[6] (i.p.), 2.25 mg/kg^[7] (i.v.)

给药途径
i.p., i.v.
参考文献

动物研究
剂量	Mice: 0.1 mg/kg^[6] (i.p.), 2.25 mg/kg^[7] (i.v.)
给药途径	i.p., i.v.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2641 mL
- 6.3206 mL
- 12.6412 mL
- 5 mM
- 0.2528 mL
- 1.2641 mL
- 2.5282 mL
- 10 mM
- 0.1264 mL
- 0.6321 mL
- 1.2641 mL

技术信息

CAS号

579-13-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H74O11

运输

蓝冰

分子量

791.06

别名

MCH 32;寡霉素A

溶解度

DMSO	9.0 mg/mL (11.4 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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