|5-(咪唑并[1,2-a]吡啶-6-基)-6-甲基-2-氧代-1,2-二氢吡啶-3-甲腈|CsnPharm

CAS No.: 106730-54-5

Olprinone/奥普力农 Catalog No. CSN10027

Synonyms: Loprinone;奥普力农

Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40 isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), the second messengers in cell functions^[3]. Olprinone is a phosphodiesterase type III inhibitor (PDEI) with both strong inotropic and vasodilatory effects that is often used in cardiac surgery for weaning from cardiopulmonary bypass (CPB). Olprinone binding to human serum protein was 80.1±4.6 % in a concentration range of 20–1000 ng/mL of olprinone. Further, olprinone binding to human serum albumin was 58.3±2.1 % at albumin concentrations of ＞3 g/dL. The olprinone concentration was 15.5±8.5 and 49.1±34.9 ng/mL just before the start of and at the beginning of withdrawal from CPB, respectively^[2]. Treatment with olprinone (0.2 mg/kg) reduced the numbers of polymorphonuclears in the BAL (bronchoalveolar lavage) fluid, decreased the formation of most oxidation markers in the lungs, reduced lung edema and prevented a decrease in TAS (total antioxidant status) in the lung homogenate compared to non-treated animals. In the blood plasma, olprinone decreased TBARS (thiobarbituric acid-reactive substances) and increased TAS compared to the non-treated group^[4].
参考文献

[1] Fuji H, Hatano E, et al. Phase I clinical trial of olprinone in liver surgery. Surg Today. 2016 Dec 27.
[2] The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone
[3] Phosphodiesterase inhibitors say NO to Alzheimer's disease
[4] Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9958 mL
- 19.9792 mL
- 39.9584 mL
- 5 mM
- 0.7992 mL
- 3.9958 mL
- 7.9917 mL
- 10 mM
- 0.3996 mL
- 1.9979 mL
- 3.9958 mL

技术信息

CAS号

106730-54-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H10N4O

运输

蓝冰

分子量

250.26

别名

Loprinone;奥普力农

溶解度

DMSO	50.0 mg/mL (199.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Olprinone/奥普力农 Catalog No. CSN10027

靶点选择性

请登录您的专属账户

确认信息