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CAS No.: 6054-98-4

Olsalazine Disodium/奥沙拉秦钠 Catalog No. CSN11606

Synonyms: Olsalazine (sodium salt);C.I. 14130;Dipentum

Olsalazine Sodium is a prodrug of mesalamine with anti-inflammatory activity used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.

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技术信息

生物活性

描述Olsalazine Sodium is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine Sodium demonstrated a great inhibitory activity for XOD (xanthine oxidase) (IC50 = 3. 4 mg/L). Enzymatic kinetic studies revealed that the drug was a hybrid-type inhibitor of xanthine oxidase. In vivo, the drug strikingly decreased serum urate levels, serum/hepatic activities of XOD at a dose-dependent manner^[3]. Olsalazine is effective for the treatment of ulcerative colitis and is well tolerated among patients intolerant to sulfasalazine^[4]. Of the patients treated with olsalazine sodium, 52. 2% achieved endoscopic remission, compared with 48. 8% of patients treated with mesalazine^[5]. Moreover, olsalazine 1 to 3g daily in divided doses improved clinical signs and symptoms of colitis in approximately 60 to 80% of patients with acute ulcerative colitis of mild to moderate severity^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01320436	Ulcerative Colitis	Phase 3	Completed	-	Israel ... more >> Sheba Medical Center Ramat Gan, Israel Collapse <<
NCT00004288	Ankylosing Spondylitis	Phase 2	Completed	-	-
NCT03423810	Polycystic Kidney Diseases	Early Phase 1	Recruiting	May 15, 2019	United States, Kansas ... more >> University of Kansas Medical Center Recruiting Kansas City, Kansas, United States, 66160 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8885 mL
- 14.4424 mL
- 28.8848 mL
- 5 mM
- 0.5777 mL
- 2.8885 mL
- 5.7770 mL
- 10 mM
- 0.2888 mL
- 1.4442 mL
- 2.8885 mL

技术信息

CAS号

6054-98-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H8N2Na2O6

运输

蓝冰

分子量

346.20

别名

Olsalazine (sodium salt);C.I. 14130;Dipentum;Olsalazine;Azodisal sodium;Azodisalicylate;CJ-91B;奥沙拉秦钠

溶解度

DMSO	4.0 mg/mL (11.6 mM)
Ethanol	Insoluble

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