|1-(3-氯-2-羟基丙基)-2-甲基-5-硝基咪唑|CsnPharm

CAS No.: 16773-42-5

Ornidazole/奥硝唑 Catalog No. CSN11615

Synonyms: Ro 7-0207;NSC-95075;Tiberal

Ornidazole is an antibiotic used to treat some protozoan infections and investigated for use in Crohn's disease after bowel resection.

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技术信息

生物活性

描述Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection^[3]. Adverse effects on the central nervous system (CNS) are the main side effects of ornidazole during its clinical application^[4]. A concentration of 3. 1 mg/mL of ornidazole inhibited 98% of the strains of B. fragilis, with greater sensitivity when ampicillin and gentamicin were also present. A concentration of 6. 2 mg/mL of ornidazole inhibited 16 of 18 strains of C. perfringens and all 11 strains of other Clostridium species^[5]. Moreover, ornidazole loaded fibers could be a potential drug delivery system for the treatment of gingivitis^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01662765	-	-	Completed	-	-
NCT00609973	Crohn's Disease	Phase 2	Completed	-	United States, North Carolina ... more >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT01662765	Pilonidal Sinus ... more >> Sinus; Dermal, Pilonidal Umbilical Granuloma Collapse <<	Not Applicable	Completed	-	Turkey ... more >> Hatem Hospital Gaziantep, Turkey, 27090 Medical Park Gaziantep Hospital Gaziantep, Turkey, 27090 25 Aralık Familiy Physician Health Center Gaziantep, Turkey, 27100 Dr.Ersin Arslan State Hospital Gaziantep, Turkey, 27100 Şehitkamil State Hospital Gaziantep, Turkey, 27100 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5532 mL
- 22.7660 mL
- 45.5320 mL
- 5 mM
- 0.9106 mL
- 4.5532 mL
- 9.1064 mL
- 10 mM
- 0.4553 mL
- 2.2766 mL
- 4.5532 mL

技术信息

CAS号

16773-42-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H10ClN3O3

运输

蓝冰

分子量

219.63

别名

Ro 7-0207;NSC-95075;Tiberal;奥硝唑

溶解度

DMSO	42.0 mg/mL (191.2 mM)
Ethanol	43.0 mg/mL (195.8 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01662765	-	-	Completed	-	-
NCT00609973	Crohn's Disease	Phase 2	Completed	-	United States, North Carolina ... more >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT01662765	Pilonidal Sinus ... more >> Sinus; Dermal, Pilonidal Umbilical Granuloma Collapse <<	Not Applicable	Completed	-	Turkey ... more >> Hatem Hospital Gaziantep, Turkey, 27090 Medical Park Gaziantep Hospital Gaziantep, Turkey, 27090 25 Aralık Familiy Physician Health Center Gaziantep, Turkey, 27100 Dr.Ersin Arslan State Hospital Gaziantep, Turkey, 27100 Şehitkamil State Hospital Gaziantep, Turkey, 27100 Collapse <<
NCT00609973	-	-	Completed	-	-
NCT03491540	Rectal Cancer Surgery	Phase 3	Not yet recruiting	August 31, 2018	France ... more >> Service de chirurgie Colorectale / Hôpital Beaujon Not yet recruiting Clichy, Ile De France, France, 92110 Contact: Justine PROST A LA DENISE, MD 33 (0)1 40 87 45 47 justine.prostaladenise@aphp.fr Contact: Yves PANIS, MD,PhD 33 (0)1 40 87 45 47 yves.panis@aphp.fr Collapse <<
NCT02618720	Elective Colorectal Surgery	Phase 3	Unknown	September 2017	France ... more >> CHU Clermont-Ferrand Recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN 04 73 75 10 81 placarin@chu-clermontferrand.fr Principal Investigator: Emmanuel FUTIER Collapse <<
NCT03475680	Colon Cancer	Phase 3	Not yet recruiting	August 31, 2021	France ... more >> Service de chirurgie Colorectale / Hôpital Beaujon Clichy, France, 92110 Collapse <<

Ornidazole/奥硝唑 Catalog No. CSN11615

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