|N,N-二甲基-2-(苯基(邻甲苯基)甲氧基)乙胺 2-羟基丙-1,2,3-三羧酸盐|CsnPharm

CAS No.: 4682-36-4

Orphenadrine citrate/枸酸芬那君 Catalog No. CSN11618

Synonyms: Banflex;Benhexal;NSC-757238

Orphenadrine Citrate is both an uncompetitive NMDA receptor antagonist IC50 value of 16.2 µM and a mAChR antagonist with IC50 value of 0.37 µM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Orphenadrine blocked open NMDA receptor channels with fast kinetics and in a strongly voltage-dependent manner. The IC50-value against steady state currents at -70 mV was 16.2 +/- 1.6 microM (n = 6). Orphenadrine exhibited relatively fast, concentration-dependent open channel blocking kinetics (Kon 0.013 +/- 0.002 10(6) M-1S-1) whereas the offset rate was concentration-independent (Koff 0.230 +/- 0.004 S-1)^[3]. In the low micromolar range, orphenadrine enhanced electrically-evoked and exogenous noradrenaline contractile responses in the epididymal portion of rat vas deferens. It also induced spontaneous activity that was inhibited by prazosin (1 microM) but not by atropine (20 nM). It inhibited accumulation of [3H]noradrenaline in rat vas deferens (IC50 = 14.2+/-2.3 microM). Orphenadrine competitively inhibited [3H]nisoxetine binding in rat vas deferens membranes (Ki = 1.05+/-0.20 microM)^[4]. Orphenadrine with a more sensory-selective action over motor block exhibited more potent and longer spinal anesthesia when compared to lidocaine^[5]. Orphenadrine given at a dose of 5.65 mg/kg elevated the electrical seizure threshold from 5.7 (5.4-6.1) to 6.8 (6.3-7.3) mA, while a dose of 2.8 mg/kg was ineffective^[6]. The combination of orphenadrine and paracetamol enhances the antinociceptive effect of either drug in mice^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01509781	in Situ Breast Cancer ... more >> Invasive Breast Cancer Collapse <<	Phase 3	Unknown	-	Hungary ... more >> National Institute of Oncology Recruiting Budapest, Hungary, 1122 Contact: Zoltan Matrai, M.D. +3612248600 ext 3302 matraidoc@gmail.com Collapse <<
NCT02456116	Pain, Postoperative	Not Applicable	Unknown	September 2015	Austria ... more >> Vienna General Hospital Recruiting Vienna, Austria, 1090 Contact: Gerhard M Hobusch, Dr. +4314040040830 gerhard.hobusch@meduniwien.ac.at Contact: Bernd Kubista, Prof. Dr. +4314040040830 bernd.kubista@meduniwien.ac.at Collapse <<
NCT02445599	Pain Inadequa... more >>te or Impaired Respiratory Function Collapse <<	Phase 4	Completed	-	Hungary ... more >> UNIVERSITY OF DEBRECEN FACULTY OF MEDICINE Department of Anesthesiology and Intensive Care Debrecen, Hajdú-Bihar, Hungary, 4032 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1668 mL
- 10.8341 mL
- 21.6682 mL
- 5 mM
- 0.4334 mL
- 2.1668 mL
- 4.3336 mL
- 10 mM
- 0.2167 mL
- 1.0834 mL
- 2.1668 mL

技术信息

CAS号

4682-36-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H31NO8

运输

蓝冰

分子量

461.50

别名

Banflex;Benhexal;NSC-757238;枸酸芬那君

溶解度

DMSO	560.0 mg/mL (1213.4 mM) warming
Water	17.0 mg/mL (36.8 mM) warming

动物实验配方

0.5% CMC-Na

70 mg/mL

suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01509781	in Situ Breast Cancer ... more >> Invasive Breast Cancer Collapse <<	Phase 3	Unknown	-	Hungary ... more >> National Institute of Oncology Recruiting Budapest, Hungary, 1122 Contact: Zoltan Matrai, M.D. +3612248600 ext 3302 matraidoc@gmail.com Collapse <<
NCT02456116	Pain, Postoperative	Not Applicable	Unknown	September 2015	Austria ... more >> Vienna General Hospital Recruiting Vienna, Austria, 1090 Contact: Gerhard M Hobusch, Dr. +4314040040830 gerhard.hobusch@meduniwien.ac.at Contact: Bernd Kubista, Prof. Dr. +4314040040830 bernd.kubista@meduniwien.ac.at Collapse <<
NCT02445599	Pain Inadequa... more >>te or Impaired Respiratory Function Collapse <<	Phase 4	Completed	-	Hungary ... more >> UNIVERSITY OF DEBRECEN FACULTY OF MEDICINE Department of Anesthesiology and Intensive Care Debrecen, Hajdú-Bihar, Hungary, 4032 Collapse <<
NCT01263652	Pain Relief	Not Applicable	Unknown	December 2013	Israel ... more >> Western Galilee Hospital Not yet recruiting Naharia, Israel Contact: Adi H Shani, R.N. , BA +97249107200 a_eilat@walla.com Contact: Nimrod Rahamimov, M.D. +972507887564 nimrod.rahamimov@naharia.health.gov.il Principal Investigator: Nimrod Rahamimov, M.D. Collapse <<
NCT02958566	Colon Cancer ... more >>Colon Diverticulosis Colonic Neoplasms Colonic Diverticulitis Pain, Postoperative Ileus Ileus Paralytic Ileus; Mechanical Constipation Drug Induced Constipation Rectum Cancer Rectum Neoplasm Collapse <<	Phase 4	Recruiting	December 2018	United States, Illinois ... more >> Uicomp Recruiting Peoria, Illinois, United States, 61603 Contact: Steven S Tsoraides, MD/MPH 309-495-0200 stsora1@uic.edu Collapse <<
NCT03493490	Pain, Postoperative ... more >> Analgesic Adverse Reaction Cruciate Ligament Rupture Collapse <<	Phase 4	Recruiting	January 31, 2019	Austria ... more >> Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Oliver Kimberger, MD PD +4340400 ext 4100 study@kimberger.at Principal Investigator: Oliver Kimberger, MD PD Collapse <<
NCT02485145	Osteoarthritis of the Hands	Early Phase 1	Unknown	March 2016	-
NCT02449369	Unilateral Knee Arthroplasty	Phase 4	Completed	-	United States, Florida ... more >> Florida Hospital Winter Park Winter Park, Florida, United States, 32792 Collapse <<
NCT02985671	Postural Low Back Pain ... more >> Mechanical Low Back Pain Collapse <<	Phase 3	Not yet recruiting	April 1, 2020	-
NCT02665286	-	-	Completed	-	-
NCT02423395	Liver Cirrhosis ... more >> Muscle Cramps Collapse <<	Phase 3	Unknown	December 2018	Egypt ... more >> Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam 00201000040794 Sherif_tropical@yahoo.com Collapse <<
NCT02665286	Low Back Pain	Phase 4	Completed	-	United States, New York ... more >> Montefiore Medical Center Bronx, New York, United States, 10467 Collapse <<

Orphenadrine citrate/枸酸芬那君 Catalog No. CSN11618

靶点选择性

请登录您的专属账户

确认信息