CAS No.: 26095-59-0
Otilonium bromide/奥替溴铵 Catalog No. CSN16263
Synonyms: Octylonium bromide;SP63;Otilonium (bromide)
Otilonium bromide is an mAchR antagonist used world-wide for the treatment of irritable bowel syndrome.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01629212 Irritable Bowel Syndrome Phase 4 Unknown February 2013 Korea, Republic of ... more >> Han Yang University Hospital Recruiting Seoul, Korea, Republic of Contact: Oh Young Lee leeoy@hanyang.ac.kr Collapse << NCT02576340 Gastroscopy Phase 4 Completed - - - 参考文献
- [1] Martinez-Cutillas M, Gil V, et al. Mechanisms of action of otilonium bromide (OB) in human cultured smooth muscle cells and rat colonic strips. Neurogastroenterol Motil. 2013 Dec;25(12):e803-12.
- [2] Forte E, Pizzoferrato M, et al. The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide. Eur Rev Med Pharmacol Sci. 2012 Jan;16(1):25-37.
- [3] Lindqvist S, Hernon J, Sharp P, Johns N, Addison S, Watson M, Tighe R, Greer S, Mackay J, Rhodes M, Lewis M, Stebbings W, Speakman C, Evangelista S, Johnson I, Williams M. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 Dec;137(7):1134-42.
- [4] Gandía L, Villarroya M, Lara B, Olmos V, Gilabert JA, López MG, Martínez-Sierra R, Borges R, García AG. Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol. 1996 Feb;117(3):463-470.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 26095-59-0 | 储存条件 |
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| 分子式 | C29H43BrN2O4 | 运输 | 蓝冰 | |||||||||
| 分子量 | 563.57 | 别名 | Octylonium bromide;SP63;Otilonium (bromide);Octylonium;奥替溴铵 | |||||||||
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动物实验配方 |
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