64211-46-7|Oxiconazole Nitrate|CsnPharm

CAS No.: 64211-46-7

Synonyms: Ro 13-8996;Oxiconazole (nitrate);Oxiconazole

Oxiconazole is an antifungal medication.

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400-920-2911

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生物活性

描述Oxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively^[1]. It acts by erogosterol biosynthesis inhibition, which causes lysis of the fungal cell membrane because of changes in both membrane integrity and fluidity and direct membrane damage of fungal cells^[2]. Applied once daily for four weeks in the treatment of tinea pedis or for two weeks in the treatment of tinea corporis, tinea cruris, and tinea versicolor, 1% oxiconazole cream has produced mycologic and clinical cures in at least 80% of patients^[3]. Oxiconazole showed a higher activity than that of econazole in Candida spp. and yeasts other than Candida^[4].
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT01519752 Tinea Pedis Phase 1 Completed - -

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01519752	Tinea Pedis	Phase 1	Completed	-	-

实验方案

技术信息

CAS号	64211-46-7	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H14Cl4N4O4	运输	蓝冰
分子量	492.14	别名	Ro 13-8996;Oxiconazole (nitrate);Oxiconazole;Oxistat;Oxizole;Fonx;Myfungar;Sgd 301-76;ST-813;硝酸奥昔康唑

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