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CAS No.: 737-52-0

Oxypeucedanin/氧化前胡素 Catalog No. CSN19790

Synonyms: 氧化前胡素

Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.It is a kind of open-channel blocker of the hKv1.5 channel.

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技术信息

生物活性

描述Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica and a selective open-channel blocker. Oxypeucedanin inhibited the hKv1.5 current in a concentration-dependent manner, with an IC(50) value of 76 nM, while it had no effect on human eag-related gene (HERG) current. Additionally, oxypeucedanin prolonged the APD (action potential duration) of rat atrial and ventricular muscles in a dose-dependent manner^[3]. Oxypeucedanin (OPD) effectively inhibited the growth of SK-Hep-1 cells. Flow cytometric analysis revealed that OPD was able to induce G2/M phase cell cycle arrest in cells. In addition, the combination of OPD with gemcitabine showed synergistic growth-inhibitory activity in SK-Hep-1 cells^[4]. Treatment with oxypeucedanin inhibited cell growth and induced cell death in DU145 cells. Furthermore, oxypeucedanin-induced cell growth inhibition was associated with an increase in G2-M arrest in cell cycle progression in DU145 cells in a dose and time-dependent manner^[5]. Microsomal incubation with oxypeucedanin induced a time-, concentration-, and NADPH-dependent inhibition of CYPs2B6 and 2D6 with kinetic values of KI/kinact 1.82 µM/0.07 min-1 (CYP2B6) and 8.47 µM/0.044 min-1 (CYP2D6), respectively^[6]. OPD reverse P-gp-mediated drug transport via inhibition of P-gp activity and P-gp protein expression as well as downregulation of P-gp mRNA level^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4931 mL
- 17.4655 mL
- 34.9309 mL
- 5 mM
- 0.6986 mL
- 3.4931 mL
- 6.9862 mL
- 10 mM
- 0.3493 mL
- 1.7465 mL
- 3.4931 mL

技术信息

CAS号

737-52-0

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14O5

运输

蓝冰

分子量

286.28

别名

氧化前胡素

溶解度

DMSO	24.0 mg/mL (83.8 mM)

动物实验配方

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