生物活性

• 描述Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products^[3]. Oxytetracycline is a bacteriostatic antibiotic. Due to its significant efficacy, limited adverse effects and low therapy costs, oxytetracycline at the dose of 500 mg per day is presently considered as therapy of choice in papulopustulous acne. Topical oxytetracycline shows significant efficacy in primary and secondary skin infections with inflammatory reaction^[4]. Claws can be a source of antimicrobial residue entry into the food chain, since OTC and its metabolite can be found in chicken's claws for long periods, even exceeding the average lifespan of a broiler chicken^[5]. Oxytetracycline (OTC) is employed in fish farms to contest or prevent bacterial infections. The OTC residual levels in muscle showed a dose-response relationship. After 10 days of treatment at the recommended dose (75 mg/kg), the mean value in muscle was 295 μg/kg. After 10 withdrawal days, residues in all treated groups were not entirely eliminated by fish^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03608774	Anal Chlamydia Infection	Phase 4	Recruiting	December 1, 2019	United States, Massachusetts ... more >> Fenway Health - The Fenway Institute Recruiting Boston, Massachusetts, United States, 02115 United States, Washington University of Washington - Harborview Medical Center - Center for AIDS and STD Recruiting Seattle, Washington, United States, 98104-2499 Collapse <<
  NCT00066066	-	-	Completed	-	-
  NCT00385515	Stomatitis Or... more >>al Mucositis Collapse <<	Phase 2	Completed	-	United States, California ... more >> Desert Hematology Oncology Medical Group Rancho Mirage, California, United States, 92270 United States, Connecticut Bridgeport Hospital Bridgeport, Connecticut, United States, 06610 Eastern Connecticut Hematology & Oncology Associates Norwich, Connecticut, United States, 06360 United States, Florida Florida Research Cancer Institute Davie, Florida, United States, 33328 United States, Minnesota Park Nicollet Clinic St Louis Park, Minnesota, United States, 55416 United States, Missouri Capitol Comprehensive Cancer Care Clinic Jefferson City, Missouri, United States, 65109 United States, Texas Cancer Specialists of South Texas Corpus Christi, Texas, United States, 78412 United States, Virginia Cancer Outreach Associates Abingdon, Virginia, United States, 24211 United States, West Virginia Morgantown Internal Medicine Group Morgantown, West Virginia, United States, 26505 India Vedanta Institute of Medical Sciences Navrangpura, Ahmedabad, Gujarat, India, 380009 Jawaharlal Nehru Cancer Hospital and Research Centre Post Box No. 32, Idgah Hills, Bhopal, Madhya Pradesh, India, 462001 Apollo Speciality Hospital 320, Mount Road, Teynampet, Chennai, Tamil Nadu, India, 600035 Dharamshila Cancer Hospital and Research Centre, Dharamshila Marg, Vasundhara Enclave, Dehli, India, 110096 Apollo Hospitals Jubilee Hills, Hyderabad, Andhra Pradesh, India, 500033 Nizams Institute of Medical Sciences Punjagutta, Hyderabad, Andhra Pradesh, India, 500082 Bhagwan Mahavir Cancer Hospital and Research Centre, Jawaharlal Nehru Marg, Jaipur, Rajasthan, India, 302017 S.K Sony Hospital, Vidyadhar Nagar, Sector-5 Sikar Road, Jaipur, Rajasthan, India, 302013 Netaji Subhash Chandra Bose Cancer Hospital & Research Institute 16A Park Lane, Kolkatta, West Bengal, India, 700016 Chittaranjan National Cancer Institute 37, S.P. Mukherjee Rd., Kolkatta, West Bengal, India, 700026 Dayanand Medical College & Hospital Tagore Nagar, Civil Lines, Ludhiana, Punjab, India, 141001 Jaslok Hospital & Research Centre 15-Dr. G. Deshmukh Marg, Mumbai, Maharashtra, India, 400026 Jehangir Hospital, 32 Sassoon Road, Pune, Maharashtra, India, 411001 Ruby Hall Clinic, 40, Sassoon Road, Pune, Maharashtra, India, 411001 Seth Ramdas Shah Memorial Hospital & Research Centre FP-402, Gokhle Nagar Road, Shivaji Nagar, Pune, Maharashtra, India, 411016 North Bengal Oncology Centre, Pradhan Nagar, Siliguri, Dist- Darjeeling, West Bengal, India, 734003 Regional Cancer Centre Medical College Campus, Post Bag No. 2417, Trivandrum, Kerala, India, 695011 Christian Medical College & Hospital IDA Scuddar Road, Vellore, Tamil Nadu, India, 632004 Collapse <<

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• 参考文献

• [1] Jayanthi R, Subash P. Antioxidant effect of caffeic Acid on oxytetracycline induced lipid peroxidation in albino rats. Indian J Clin Biochem. 2010 Oct;25(4):371-5.

  [2] Pari L, Gnanasoundari M. Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol. 2006 May;98(5):456-61.

  [3] Pickens LB, Tang Y. Oxytetracycline biosynthesis. J Biol Chem. 2010;285(36):27509‐27515

  [4] Olszewska M. Mechanizm działania i zastosowanie oksytetracykliny w chorobach skóry [Oxytetracycline--mechanism of action and application in skin diseases]. Wiad Lek. 2006;59(11-12):829-833.

  [5] Cornejo J, Pokrant E, Araya D, et al. Residue depletion of oxytetracycline (OTC) and 4-epi-oxytetracycline (4-epi-OTC) in broiler chicken's claws by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017;34(4):494‐500

  [6] Elia AC, Ciccotelli V, Pacini N, et al. Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem. 2014;40(4):1055‐1068

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