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CAS No.: 245765-41-7

Ozenoxacin/奥泽沙星 Catalog No. CSN23836

Synonyms: T-3912;GF-001001-00;M-5120

Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

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技术信息

生物活性

描述Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections. Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes^[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10^-10 and 5.3 × 10^-10, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin^[2]. Ozenoxacin, a novel non-fluorinated topical quinolone antimicrobial, has demonstrated efficacy in impetigo. In vitro studies have demonstrated high potency of ozenoxacin against staphylococci and streptococci including resistant strains of S. aureus. Clinical trials of ozenoxacin in patients with impetigo reported high clinical and microbiological success rates^[3].
参考文献

[1] López Y, Tato M, Espinal P, et al. In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. Antimicrob Agents Chemother. 2013;57(12):6389-6392
[2] López Y, Tato M, Espinal P, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. J Antimicrob Chemother. 2015;70(1):57-61
[3] Vila J, Hebert AA, Torrelo A, et al. Ozenoxacin: a review of preclinical and clinical efficacy. Expert Rev Anti Infect Ther. 2019;17(3):159-168

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7517 mL
- 13.7586 mL
- 27.5172 mL
- 5 mM
- 0.5503 mL
- 2.7517 mL
- 5.5034 mL
- 10 mM
- 0.2752 mL
- 1.3759 mL
- 2.7517 mL

技术信息

CAS号

245765-41-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H21N3O3

运输

蓝冰

分子量

363.41

别名

T-3912;GF-001001-00;M-5120;Xepi;奥泽沙星

溶解度

DMSO	5.0 mg/mL (13.8 mM)
Water	Insoluble
Ethanol	Insoluble

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