CAS No.: 186953-56-0
Pafuramidine/帕呋拉定 Catalog No. CSN18057
Synonyms: DB289;帕呋拉定
Pafuramidine is an orally bioavailable prodrug of furamidine, which has clinical activity against Pneumocystis pneumonia.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00302341 Pneumonia, Interstitial Plasma... more >> Cell Pneumocystis Carinii Pneumonia Pneumonia, Pneumocystis Carinii HIV Infections Collapse << Phase 3 Terminated(FDA Clinical Hold a... more >>s of 12/21/07 due to safety concerns) Collapse << - United States, California ... more >> University of California San Francisco, California, United States, 94110 United States, Illinois The University of Chicago Chicago, Illinois, United States, 60637 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 United States, New York NYU School of Medicine New York, New York, United States, 10016 United States, North Carolina UNC AIDS Clinical Trials Chapel Hill, North Carolina, United States, 27599-7030 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45267-0405 United States, South Carolina Medical University of SC Charleston, South Carolina, United States, 29425 Collapse << NCT00802594 Trypanosomiasis, African Phase 2 Completed - Angola ... more >> Laboratory of Reference and Investigation, Viana, ICCT Bairro Ingombota, Luanda, Angola, CP 2657-C Congo Programme National de Lutte contre la Trypanosomiase Kinshasa, Gombe, Congo Collapse << NCT00803933 African Trypanosomiasis Phase 2 Completed - Congo ... more >> CDTC Maluku Gombe, Kinshasa, Congo Vanga Hospital Gombe, Kinshasa, Congo Collapse << - 更多
- 参考文献
- [1] Midgley I, Fitzpatrick K, et al. Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl] furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride). Drug Metab Dispos. 2007 Jun;35(6):955-67.
- [2] Lanteri CA, Trumpower BL, et al. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2004 Oct;48(10):3968-74.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 186953-56-0 | 储存条件 |
|
|
| 分子式 | C20H20N4O3 | 运输 | 蓝冰 | |
| 分子量 | 364.39 | 别名 | DB289;帕呋拉定 |
