|(E)-4-(2-(3-((1H-吡唑-1-基)甲基)-5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)乙烯基)苯甲酸|CsnPharm

CAS No.: 410528-02-8

Palovarotene Catalog No. CSN18263

Synonyms: R 667;Ro 3300074

Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema.

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技术信息

生物活性

描述Palovarotene is a selective retinoic acid receptor gamma (RAR-γ) agonist for the treatment of emphysema.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02322255	-	-	Active, not recruiting	October 2019	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Pennsylvania University of Pennsylvania, Center for FOP & Related Bone Disorders Philadelphia, Pennsylvania, United States, 19104 Argentina Hospital Italiano de Buenos Aires, Department of Pediatrics Buenos Aires, Argentina Australia, Queensland Queensland University of Technology (QUT) Institute of Health and Biomedical Innovation (IHBI) Woolloongabba, Queensland, Australia, 4102 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France Italy Gaslini Institute, Unit of Rare Diseases, Department of Pediatrics Genoa, Italy United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT02279095	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Active, not recruiting	March 2021	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Minnesota Mayo Clinic, Department of Medicine Rochester, Minnesota, United States, 55905 United States, Pennsylvania University of Pennsylvania, Center for FOP & Related Bone Disorders Philadelphia, Pennsylvania, United States, 19104 Argentina Hospital Italiano de Buenos Aires, Department of Pediatrics Buenos Aires, Argentina Australia, Queensland Queensland University of Technology (QUT) Institute of Health and Biomedical Innovation (IHBI) Woolloongabba, Queensland, Australia, 4102 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT02190747	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Completed	-	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Pennsylvania University of Pennsylvania, Center for Research in FOP & Related Disorders Philadelphia, Pennsylvania, United States, 19104 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<

更多
参考文献

[1] Pavey GJ, Qureshi AT, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.
[2] Chakkalakal SA, Uchibe K, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31(9):1666-75.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4123 mL
- 12.0616 mL
- 24.1232 mL
- 5 mM
- 0.4825 mL
- 2.4123 mL
- 4.8246 mL
- 10 mM
- 0.2412 mL
- 1.2062 mL
- 2.4123 mL

技术信息

CAS号	410528-02-8	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H30N2O2	运输	蓝冰
分子量	414.54	别名	R 667;Ro 3300074

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02322255	-	-	Active, not recruiting	October 2019	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Pennsylvania University of Pennsylvania, Center for FOP & Related Bone Disorders Philadelphia, Pennsylvania, United States, 19104 Argentina Hospital Italiano de Buenos Aires, Department of Pediatrics Buenos Aires, Argentina Australia, Queensland Queensland University of Technology (QUT) Institute of Health and Biomedical Innovation (IHBI) Woolloongabba, Queensland, Australia, 4102 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France Italy Gaslini Institute, Unit of Rare Diseases, Department of Pediatrics Genoa, Italy United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT02279095	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Active, not recruiting	March 2021	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Minnesota Mayo Clinic, Department of Medicine Rochester, Minnesota, United States, 55905 United States, Pennsylvania University of Pennsylvania, Center for FOP & Related Bone Disorders Philadelphia, Pennsylvania, United States, 19104 Argentina Hospital Italiano de Buenos Aires, Department of Pediatrics Buenos Aires, Argentina Australia, Queensland Queensland University of Technology (QUT) Institute of Health and Biomedical Innovation (IHBI) Woolloongabba, Queensland, Australia, 4102 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT02190747	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Completed	-	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Pennsylvania University of Pennsylvania, Center for Research in FOP & Related Disorders Philadelphia, Pennsylvania, United States, 19104 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT02979769	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Active, not recruiting	December 2018	France ... more >> Hôpital Necker-Enfants Malades, Department of Genetics Paris, France Collapse <<
NCT03442985	Exostoses, Multiple Hereditary	Phase 2	Recruiting	February 2021	United States, California ... more >> Children's Orthopaedic Center Recruiting Los Angeles, California, United States, 90027 Contact: Regina Woon 323-361-2843 rwoon@chla.usc.edu Principal Investigator: Vernon T Tolo, MD Sub-Investigator: Rachel Y Goldstein, MD, MPH University of California-San Francisco Recruiting San Francisco, California, United States, 94158 Contact: Emma Canepa 415-502-2425 Emma.Canepa@ucsf.edu Principal Investigator: Jessica Tenney, MD Sub-Investigator: Edward Hsiao, MD Sub-Investigator: Janet Lee, MD United States, Florida Paley Orthopedic and Spine Institute Recruiting West Palm Beach, Florida, United States, 330407 Contact: Troy Rand 561-531-1553 trand@paleyinstitute.org Principal Investigator: David Feldman, MD United States, Illinois Shriners Hospital for Children - Chicago Recruiting Chicago, Illinois, United States, 60707 Contact: Sahar Hassani, MS 773-622-5400 shassani@shrinenet.org Principal Investigator: Jeffrey Ackman, MD Sub-Investigator: Haluk Altiok, MD Sub-Investigator: Purnendu Gupta, MD Sub-Investigator: Peter Smith, MD United States, Massachusetts Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Andrea Hale 167-135-5600 Andrea.Hale@childrens.harvard.edu Principal Investigator: Christina Jacobsen, MD Sub-Investigator: Ingrid Holm, MD, MPH Sub-Investigator: Samantha Spencer, MD United States, Pennsylvania The Children's Hospital of Philadelphia (CHOP) Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Vashisht Arshanapally, BS 267-426-7482 arshanapav@email.chop.edu Principal Investigator: Michael A Levine, MD Sub-Investigator: Edna Mancilla, MD Shriners Hospital for Children - Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19410-4160 Contact: Jamie Landgarten, MS 215-430-4239 jlandgarten@shrinenet.org Principal Investigator: Bethany Lipa, MD United States, Texas Memorial Hermann Hospital Recruiting Houston, Texas, United States, 77030 Contact: Mayank Rao 713-704-2639 Mayank.Rao@uth.tmc.edu Principal Investigator: Ernest Conrad, MD Sub-Investigator: Shiraz Younas, MD Canada, Ontario Hospital for Sick Children Recruiting Toronto, Ontario, Canada, M5G 1X8 Contact: Tony (Yongyao) Tan (416) 813-7654 ext 203575 tony.tan@sickkids.ca Principal Investigator: Roberto Mendoza-Londono, MD Sub-Investigator: Lucie Dupuis, MD Sub-Investigator: Andrew Howard, MD Sub-Investigator: Jennifer Stimec, MD Sub-Investigator: Irene Lara-Corrales, MD Sub-Investigator: Peter Kannu, MD Japan Nagoya University Hospital Recruiting Nagoya, Aichi, Japan Contact: Kumiko Tsukamoto +81-52-561-0166 kumiko-tsukamoto@irom.co.jp Principal Investigator: Hiroshi Kitoh, MD Sub-Investigator: Kenichi Mishima, MD Sub-Investigator: Tadashi Nagata, MD Sub-Investigator: Masaki Matsushita, MD Osaka University Hospital Recruiting Suita, Osaka, Japan, 565-0871 Contact: Hiromi Tanaka (SC) +81662108290 h-tanaka@dmi.med.osaka-u.ac.jp Principal Investigator: Keiichi Ozono, MD, PhD Sub-Investigator: Taichi Kitaoka, MD Sub-Investigator: Hiroyuki Saitou, MD Sub-Investigator: Dr. Kiyoshi Yoshida Sub-Investigator: Dr. Hidetatsu Otani Sub-Investigator: Dr. Kenichiro Hamada Sub-Investigator: Dr. Satoshi Takenaka Sub-Investigator: Hiroto Takahashi, MD Collapse <<
NCT02521792	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 2	Suspended(Subjects were enroll... more >>ed into a different Phase 2 study (PVO-1A-202, NCT02279095).) Collapse <<	December 2018	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Pennsylvania University of Pennsylvania, Center for Research in FOP & Related Disorders Philadelphia, Pennsylvania, United States, 19104 France Hôpital Necker-Enfants Malades, Department of Genetics Paris, France United Kingdom The Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex, United Kingdom, HA7 4LP Collapse <<
NCT03312634	Fibrodysplasia Ossificans Prog... more >>ressiva Collapse <<	Phase 3	Active, not recruiting	November 2020	United States, California ... more >> University of California San Francisco, Division of Endocrinology and Metabolism San Francisco, California, United States, 94143 United States, Minnesota Mayo Clinic - 200 1st Street Southwest Rochester, Minnesota, United States, 55905 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Argentina Hospital Italiano de Buenos Aires, Tte General Juan Domingo Peron 4190 Buenos Aires, Argentina, C1199ABB Australia, Queensland Queensland University of Technology, Institute of Health and Biomedical Innovation, TRI, Level 3 Woolloongabba, Queensland, Australia, 4102 Brazil Hospital Israelita Albert Einstein Sao Paulo, SP, Brazil, 05652-900 Canada, Ontario Hospital for Sick Children, 555 University Avenue Toronto, Ontario, Canada, M5G 1X8 Toronto General Hospital Toronto, Ontario, Canada, M5G 2C4 France Groupe Hospitalier Necker Enfants Malades Paris, France, 75015 Italy Istituto Giannina Gaslini, Department of Pediatrics, Unit of Rare Diseases Genova, Liguria, Italy, 16148 Japan The University of Tokyo Hospital Tokyo, Bunkyo-ku, Japan, 113-8655 Spain Hospital Universitari i Politècnic La Fe, Unidad de Reumatología Pediatrica Valencia, Avinguda De Fernando Abril Martorell, Nº 106, Spain, 46026 Sweden Norrlands Universitetssjukhus Umeå, Sweden, SE-90185 United Kingdom Royal National Orthopaedic Hospital, Brockely Hill Stanmore, United Kingdom, HA7 4LP Collapse <<

Palovarotene Catalog No. CSN18263

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