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CAS No.: 269718-84-5
Synonyms: SLV-308;DU-126891;SME-308
Pardoprunox is a partial dopamine D2 (pKi = 8.1) and D3 (pKi = 8.6) receptor agonist (IA = 50% and 67%, respectively) and full serotonin 5-HT1A (pKi = 8.5) receptor agonist (IA = 100%), and also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00335166 | Early Stage Parkinson Disease | Phase 3 | Completed | - | - |
NCT00269516 | Early Stage Parkinson's Diseas... more >>e Collapse << | Phase 3 | Completed | - | - |
NCT00406588 | Advanced Stage Parkinson's Dis... more >>ease Collapse << | Phase 3 | Completed | - | - |
实验方案
技术信息
CAS号 | 269718-84-5 | 储存条件 |
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分子式 | C12H15N3O2 | 运输 | 蓝冰 | |
分子量 | 233.27 | 别名 | SLV-308;DU-126891;SME-308 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00335166 | Early Stage Parkinson Disease | Phase 3 | Completed | - | - |
NCT00269516 | Early Stage Parkinson's Diseas... more >>e Collapse << | Phase 3 | Completed | - | - |
NCT00406588 | Advanced Stage Parkinson's Dis... more >>ease Collapse << | Phase 3 | Completed | - | - |
NCT00407095 | Advanced Stage Parkinson's Dis... more >>ease Collapse << | Phase 3 | Completed | - | - |
NCT00903838 | Advanced Stage Parkinson's Dis... more >>ease Collapse << | Phase 2 | Terminated(The study was termi... more >>nated on 31 May, 2011, due to strategic considerations.) Collapse << | - | Germany ... more >> Site Reference ID/Investigator# 45433 Goettingen, Germany, 37075 Site Reference ID/Investigator# 45428 Kassel, Germany, 34128 Site Reference ID/Investigator# 45422 Tuebingen, Germany, BW 72076 Site Reference ID/Investigator# 45427 Ulm, Germany, 89081 Italy Site Reference ID/Investigator# 45435 Cassino, Italy, 03043 Site Reference ID/Investigator# 45436 Chieti Scalo, Italy, 66013 Site Reference ID/Investigator# 45437 Rome, Italy, 00163 Portugal Site Reference ID/Investigator# 45438 Coimbra, Portugal, 3000-075 Site Reference ID/Investigator# 45439 Lisbon, Portugal, 1649-035 Collapse << |
NCT00332917 | Early Stage Parkinson's Diseas... more >>e Collapse << | Phase 3 | Completed | - | - |
NCT00134251 | Parkinson's Disease | Phase 3 | Completed | - | Bulgaria ... more >> Site 16 Plovdiv, Bulgaria Site 11 Sofia, Bulgaria Site 12 Sofia, Bulgaria Site 13 Sofia, Bulgaria Site 14 Sofia, Bulgaria Site 15 Sofia, Bulgaria Malta Site 21 Guardamangia, Malta Serbia Site 31 Belgrade, Serbia Site 34 Belgrade, Serbia Site 33 Nis, Serbia Collapse << |
NCT00335374 | Early Stage Parkinson's Diseas... more >>e Collapse << | Phase 3 | Completed | - | - |
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