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CAS No.: 306-07-0

Pargyline HCl/帕吉林盐酸盐 Catalog No. CSN11654

Synonyms: Pargylamine hydrochloride;Pargylamine HCl;Pargyline (hydrochloride)

Pargyline HCl is an irreversible and selective MAO-B inhibitor with Ki values of 15 and 1.8 μM for MAO-A and MAO-B, respectively.

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生物活性

描述Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively^[2]. Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner. Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner. Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells. Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression^[3]. Moreover, a low dose of pargyline injected directly into the brain lowered arterial pressure^[4]. Pargyline decrease STEP (striatal-enriched protein tyrosine phosphatase) activity in the D. rerio brain, without affecting the level of the ptpn5 mRNA gene^[5]. Pargyline (100 mg/kg) increased the concentration of cerebral noradrenaline dopamine and 5-hydroxytryptamine in the mouse^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.1101 mL
- 25.5506 mL
- 51.1012 mL
- 5 mM
- 1.0220 mL
- 5.1101 mL
- 10.2202 mL
- 10 mM
- 0.5110 mL
- 2.5551 mL
- 5.1101 mL

技术信息

CAS号

306-07-0

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H14ClN

运输

蓝冰

分子量

195.69

别名

Pargylamine hydrochloride;Pargylamine HCl;Pargyline (hydrochloride);NSC 43798;Pargyline Hydrochloride;N-benzyl-N-methylprop-2-yn-1-amine hydrochloride;Eutonyl-ten;N-Methyl-N-propargylbenzylamine hydrochloride;Pargyline HCl;Pargyline;优降宁盐酸盐;盐酸帕吉林;巴吉林盐酸盐

溶解度

DMSO	39.0 mg/mL (199.3 mM)
Ethanol	39.0 mg/mL (199.3 mM)

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