|Chonglou saponin VII游离|CsnPharm

CAS No.: 68124-04-9

Paris saponin VII/重楼皂苷 VII Catalog No. CSN19995

Synonyms: Chonglou Saponin VII;重楼皂苷 VII

Chonglou saponin VII, a natural product isolated and purified from the roots of Paris polyphylla, shows inhibitory effects on cell proliferation.

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技术信息

生物活性

描述Chonglou Saponin VII (Paris saponin VII, PSVII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. PSVII (Paris saponin VII) could inhibit the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. PSVII significantly suppressed cell proliferation by cell cycle arrest in the G0/G1 phase. Moreover, PSVII could attenuate mitochondrial membrane potential, increase the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decrease the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. PSVII induced a robust autophagy in K562/ADR cells^[2]. The half maximal inhibitory concentration (IC50) value of PS VII for the growth inhibition of Hela cells was 2.62 ± 0.11 μM^[3]. Treatment with PSVII influenced cell viability of MCF-7/ADR cells, as well as sensitized MCF-7/ADR cells to the cytotoxic effects of adriamycin. Moreover, PSVII significantly downregulated MDR1 (multidrug-resistant) expression in MCF-7/ADR cells. Intravenous administration of PSVII significantly enhanced anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice^[4].
参考文献

[1] Yang R, Qi J, et al. [Effects of Paris polyphylla saponin VII plus silica nano composite on ovarian cancer drug resistance in vitro] . Zhonghua Yi Xue Za Zhi. 2015 Jun 16;95(23):1859-61. Chinese.
[2] Yan T, Hu G, Wang A, Sun X, Yu X, Jia J. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907
[3] Zhang W, Zhang D, Ma X, Liu Z, Li F, Wu D. Paris saponin VII suppressed the growth of human cervical cancer Hela cells. Eur J Med Res. 2014 Aug 15;19(1):41
[4] Li Y, Sun Y, Tang T, Niu Y, Li X, Xie M, Jin H, Mei Q. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9698 mL
- 4.8488 mL
- 9.6976 mL
- 5 mM
- 0.1940 mL
- 0.9698 mL
- 1.9395 mL
- 10 mM
- 0.0970 mL
- 0.4849 mL
- 0.9698 mL

技术信息

CAS号

68124-04-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C51H82O21

运输

蓝冰

分子量

1031.18

别名

Chonglou Saponin VII;重楼皂苷 VII

溶解度

DMSO	420.0 mg/mL (407.3 mM)
Water	insoluble

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Paris saponin VII/重楼皂苷 VII Catalog No. CSN19995

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