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CAS No.: 152121-53-4

PD 169316 Catalog No. CSN13817

Synonyms: PD169316

PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述PD 169316 is a potent and selective p38 MAP kinase inhibitor. It blocked p38 enzyme activity activated by serum-starvation and apoptosis by approximately 80% in Rat-1 fibroblasts at concentration of 10μM. PD169316 at 5μM or higher abrogated signaling initiated by both TGFβ and Activin A, but not BMP4, in CaOV3 cells. PD169316 at 10μM blocked the apoptotic process induced upon LIF withdrawal, without impairing cell differentiation, in mouse ES cells, with decreased FGF-5 and increased Bcl-2 expression on RNA level observed post 3 days.
动物研究
剂量
Mice: 60 mg/kg^[4] (p.o.); 1 mg/kg^[5] (i.m.)

给药途径
p.o., i.m.
参考文献

动物研究
剂量	Mice: 60 mg/kg^[4] (p.o.); 1 mg/kg^[5] (i.m.)
给药途径	p.o., i.m.

[1] Kummer JL, Rao PK, et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272(33):20490-4.
[2] Fu Y, O'Connor LM, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.
[3] Duval D, Malaisé M, et al. A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. Cell Death Differ. 2004 Mar;11(3):331-41.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7751 mL
- 13.8757 mL
- 27.7515 mL
- 5 mM
- 0.5550 mL
- 2.7751 mL
- 5.5503 mL
- 10 mM
- 0.2775 mL
- 1.3876 mL
- 2.7751 mL

技术信息

CAS号

152121-53-4

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H13FN4O2

运输

蓝冰

分子量

360.34

别名

PD169316

溶解度

DMSO	10.5 mg/mL (29.1 mM)
Water	insoluble

动物实验配方

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PD 169316 Catalog No. CSN13817

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