CAS No.: 194423-15-9
PD168393 Catalog No. CSN16908
Synonyms: PD168393
PD168393 is an inhibitor that targets EGFR with IC50 of 0.70 nM irreversibly. It is not active against insulin, PDGFR, FGFR and PKC.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 EGFR
IC50:0.70nM- 描述
- 作用机制
- 参考文献
- [1] Bose R, Molina H, et al. Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9773-8.
- [2] David W. F, Alexander J. B, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20): 12022–12027.
- [3] Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76. doi: 10.1021/jm9503613. PMID: 8568816.
- [4] Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. doi: 10.1073/pnas.95.20.12022. PMID: 9751783; PMCID: PMC21758.
- [5] Bose R, Molina H, Patterson AS, Bitok JK, Periaswamy B, Bader JS, Pandey A, Cole PA. Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9773-8. doi: 10.1073/pnas.0603948103. Epub 2006 Jun 19. PMID: 16785428; PMCID: PMC1502529.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 194423-15-9 | 储存条件 |
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| 分子式 | C17H13BrN4O | 运输 | 蓝冰 | |||||||
| 分子量 | 369.22 | 别名 | PD168393 | |||||||
| 溶解度 |
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动物实验配方 |
