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CAS No.: 13137-64-9

Periplocin/杠柳毒苷 Catalog No. CSN25211

Synonyms: 杠柳毒苷

Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

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技术信息

生物活性

描述Periplocin (PP) is a cardiotonic steroid isolated from Periploca forrestii (PF). Periplocin is the highest level of cardiotonic steroid included in PF. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. Periplocin (5 - 20 μM; 48 hours; L929 cells) treatment shows increased proliferation up to 131% at 20 μM. It increases phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner. Periplocin (5 - 20 μM; 48 hours) significantly promotes migration of fibroblast cell and increases collagen production in L929 fibroblast. Periplocin induces Na/KATPase mediates the activation of Src/ERK and PI3K/Akt pathways^[1]. In addition, intraperitoneal injection (IP) of periplocin repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice^[2]. Periplocin inhibits the proliferation of gastric cancer cells and induces apoptosis in vitro and in vivo, indicating its potential to be used as an antitumor drug^[3]. Periplocin led to growth inhibition and apoptosis induction by changing the expression of death receptors and inducing DNA double strand breaks in SW-872 cells^[4].
参考文献

[1] Chen L, Jiang P, Li J, et al. Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. Phytomedicine. 2019;57:72‐83
[2] Cheng CF, Lu IH, Tseng HW, et al. Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs. Evid Based Complement Alternat Med. 2013;2013:958025
[3] Li L, Zhao LM, Dai SL, et al. Periplocin Extracted from Cortex Periplocae Induced Apoptosis of Gastric Cancer Cells via the ERK1/2-EGR1 Pathway. Cell Physiol Biochem. 2016;38(5):1939‐1951
[4] Lohberger B, Wagner S, Wohlmuther J, et al. Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis. Phytomedicine. 2018;51:162‐170

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4351 mL
- 7.1754 mL
- 14.3509 mL
- 5 mM
- 0.2870 mL
- 1.4351 mL
- 2.8702 mL
- 10 mM
- 0.1435 mL
- 0.7175 mL
- 1.4351 mL

技术信息

CAS号

13137-64-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C36H56O13

运输

蓝冰

分子量

696.82

别名

杠柳毒苷

溶解度

DMSO	100.0 mg/mL (143.5 mM)

动物实验配方

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