CAS No.: 1109276-89-2
PF-04620110 Catalog No. CSN13559
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01166217 Healthy Phase 1 Completed - Singapore ... more >> Pfizer Investigational Site Singapore, Singapore, 188770 Collapse << NCT01064492 Healthy Volunteers Phase 1 Completed - Belgium ... more >> Pfizer Investigational Site Bruxelles, Belgium, 1070 Collapse << NCT01474941 Healthy Phase 1 Completed - Belgium ... more >> Pfizer Investigational Site Bruxelles, Belgium, B-1070 Collapse << - 更多
- 参考文献
- [1] Lee KR, Choi SH, et al. Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies. Biomed Chromatogr. 2013 Jul;27(7):846-52.
- [2] Dow RL, Andrews M, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d] pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1109276-89-2 | 储存条件 |
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| 分子式 | C21H24N4O4 | 运输 | 蓝冰 | |
| 分子量 | 396.44 | 别名 |
