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CAS No.: 908115-27-5
Synonyms: SNX-5422;PF-4929113
PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00647764 | Solid Tumor Malignancy ... more >> Lymphoid Malignancy (Lymphoma and CLL) Leukemia Lymphoma Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Pfizer Investigational Site Bethesda, Maryland, United States, 20892 Collapse << |
NCT00506805 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> Pfizer Investigational Site Scottsdale, Arizona, United States, 85258 United States, Tennessee Pfizer Investigational Site Nashville, Tennessee, United States, 37203 Collapse << |
NCT00595686 | Hematologic Neoplasms | Phase 1 | Completed | - | United States, Georgia ... more >> Pfizer Investigational Site Augusta, Georgia, United States, 30912 United States, North Carolina Pfizer Investigational Site Chapel Hill, North Carolina, United States, 27599 United States, Pennsylvania Pfizer Investigational Site Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Pfizer Investigational Site Nashville, Tennessee, United States, 37232 Collapse << |
实验方案
技术信息
CAS号 | 908115-27-5 | 储存条件 |
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分子式 | C25H30F3N5O4 | 运输 | 蓝冰 | |||||||||||
分子量 | 521.53 | 别名 | SNX-5422;PF-4929113 | |||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00647764 | Solid Tumor Malignancy ... more >> Lymphoid Malignancy (Lymphoma and CLL) Leukemia Lymphoma Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Pfizer Investigational Site Bethesda, Maryland, United States, 20892 Collapse << |
NCT00506805 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> Pfizer Investigational Site Scottsdale, Arizona, United States, 85258 United States, Tennessee Pfizer Investigational Site Nashville, Tennessee, United States, 37203 Collapse << |
NCT00595686 | Hematologic Neoplasms | Phase 1 | Completed | - | United States, Georgia ... more >> Pfizer Investigational Site Augusta, Georgia, United States, 30912 United States, North Carolina Pfizer Investigational Site Chapel Hill, North Carolina, United States, 27599 United States, Pennsylvania Pfizer Investigational Site Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Pfizer Investigational Site Nashville, Tennessee, United States, 37232 Collapse << |
NCT01635712 | Cancer | Phase 1 | Completed | - | United States, California ... more >> UC Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Georgia Georgia Regents University Cancer Center Augusta, Georgia, United States, 30901 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37212 Collapse << |
NCT01892046 | Cancer | Phase 1 | Completed | - | United States, District of Col... more >>umbia Georgetown University Medical Center Washington, D.C., District of Columbia, United States, 20007 United States, Georgia Georgia Regents University Cancer Center Augusta, Georgia, United States, 30912 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
NCT00644072 | Lymphoma Neop... more >>lasms Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT01851096 | Cancer | Phase 1 | Completed | - | United States, District of Col... more >>umbia Georgetown University Medical Center Washington, District of Columbia, United States, 20007 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
NCT01611623 | Cancer | Phase 1 | Completed | - | - |
NCT02612285 | Cancer | Phase 2 | Terminated(Recruitment very sl... more >>ow - study could not be enrolled) Collapse << | - | United States, Arizona ... more >> HonorHealth Research Institute Scottsdale, Arizona, United States, 85258 United States, Georgia Augusta University Augusta, Georgia, United States, 30912 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Ohio Gabrail Cancer Center Research Canton, Ohio, United States, 44718 Wexner Medical Center, Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
NCT02612285 | - | - | Terminated(Recruitment very sl... more >>ow - study could not be enrolled) Collapse << | - | - |
NCT02973399 | Cancer | Phase 1 | Active, not recruiting | February 2019 | United States, New York ... more >> Weill Cornell Medical College New York, New York, United States, 10065 United States, Ohio Wexner Medical Center, Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
NCT01848756 | - | - | Terminated(Business reasons) | - | - |
NCT01848756 | Cancer | Phase 1 Phase 2 | Terminated(Business reasons) | - | United States, Arizona ... more >> Scottsdale Healthcare Scottsdale, Arizona, United States, 85258 United States, District of Columbia Georgetown University Medical Center Washington, District of Columbia, United States, 20007 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
NCT02063958 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> Mayo Clinic Scottsdale, Arizona, United States, 85259-5499 United States, California Stanford Medicine Stanford, California, United States, 94305 United States, District of Columbia Georgetown University Medical Center Washington, District of Columbia, United States, 20007 United States, Maryland Center for Cancer Research, National Cancer Institute Bethesda, Maryland, United States, 20892 United States, New Jersey hackensack University Medical Center Hackensack, New Jersey, United States, 07601 Collapse << |
NCT02914327 | Cancer | Phase 1 | Withdrawn(Lack of enrollment) | - | United States, Ohio ... more >> Wexner Medical Center, Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
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