生物活性

• 描述PF-06380101 is a cytotoxic Dolastatin 10 analogue and with excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02222922	Neoplasms	Phase 1	Recruiting	April 13, 2020	United States, Alabama ... more >> University of Alabama at Birmingham Active, not recruiting Birmingham, Alabama, United States, 35233 University of Alabama at Birmingham Active, not recruiting Birmingham, Alabama, United States, 35249 United States, Arizona Scottsdale Healthcare Hospitals DBA HonorHealth Recruiting Scottsdale, Arizona, United States, 85258 Virginia G. Piper Cancer Center Pharmacy Recruiting Scottsdale, Arizona, United States, 85258 United States, California Stanford Health Care Ocular and Orbital Oncology Recruiting Palo Alto, California, United States, 94303 University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 University of California Davis Medical Center Recruiting Sacramento, California, United States, 95817 Stanford Cancer Center Recruiting Stanford, California, United States, 94305 Stanford Hospital and Clinics Recruiting Stanford, California, United States, 94305 Stanford University School of Medicine Recruiting Stanford, California, United States, 94305 United States, Illinois The University of Chicago Medical Center, CCD Recruiting Chicago, Illinois, United States, 60637 University of Chicago Medicine Recruiting Chicago, Illinois, United States, 60637 United States, Michigan START Midwest Active, not recruiting Grand Rapids, Michigan, United States, 49546 United States, Missouri Barnes-Jewish Hospital Recruiting Saint Louis, Missouri, United States, 63110 Washington University Infusion Center Pharmacy Recruiting Saint Louis, Missouri, United States, 63110 Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 United States, Texas South Texas Accelerated Research Therapeutics, LLC Active, not recruiting San Antonio, Texas, United States, 78229 United States, Virginia Fairfax Radiology Consultants- Woodburn Recruiting Annandale, Virginia, United States, 22003 Inova Fairfax Hospital Woodburn GYN Infusion Center Recruiting Annandale, Virginia, United States, 22003 Inova Fairfax Hospital Woodburn Pharmacy Recruiting Annandale, Virginia, United States, 22003 Mid Atlantic Gynecologic Oncology and Pelvic Surgery Associates (MAGOPSA) Recruiting Annandale, Virginia, United States, 22003 Inova Schar Cancer Institute Recruiting Fairfax, Virginia, United States, 22031 Inova Loudon Hospital Recruiting Leesburg, Virginia, United States, 20176 Spain Hospital Universitario Fundacion Jimenez Diaz Recruiting Madrid, Spain, 28040 Hospital Universitario Madrid Sanchinarro Recruiting Madrid, Spain, 28050 Collapse <<
  NCT02122146	Neoplasms	Phase 1	Terminated(The study was prema... more >>turely discontinued due to a business-related decision on 09-FEB-2016. The decision to terminate the trial was based on the overall results.) Collapse <<	-	United States, California ... more >> Keck Hospital of USC Los Angeles, California, United States, 90033 LAC&USC Medical Center Los Angeles, California, United States, 90033 USC/Norris Comprehensive Cancer Center / Investigational Drug Services Los Angeles, California, United States, 90033 USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, Colorado Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 University of Colorado Denver CTO (CTRC) Aurora, Colorado, United States, 80045 University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Washington Swedish Medical Center Seattle, Washington, United States, 98104 Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 University of Washington Medical Center Seattle, Washington, United States, 98195 Collapse <<
  NCT02122146	-	-	Terminated(The study was prema... more >>turely discontinued due to a business-related decision on 09-FEB-2016. The decision to terminate the trial was based on the overall results.) Collapse <<	-	-

• 参考文献

• [1] Rago B, Tumey LN, et al. Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker. Bioconjug Chem. 2017 Feb 15;28(2):620-626.

  [2] Maderna A, Doroski M, et al. Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J Med Chem. 2014 Dec 26;57(24):10527-43.