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CAS No.: 898044-15-0

PF-3758309 Catalog No. CSN17173

Synonyms: PF-03758309;PF-309

PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 PAK4

IC50:1.3nM
描述PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
human MDA-MB-436 cells	-	Cytotoxic assay	24-48 h	Cytotoxicity against human MDA-MB-436 cells assessed as reduction in cell viability after 24 to 48 hrs by Celltiter-glo luminescence assay, IC50=0.79 nM	24432870

参考文献

[1] Ryu BJ, Lee H, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings. Mol Cell Biochem. 2014 Apr;389(1-2):69-77.
[2] Murray BW, Guo C, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0382 mL
- 10.1911 mL
- 20.3822 mL
- 5 mM
- 0.4076 mL
- 2.0382 mL
- 4.0764 mL
- 10 mM
- 0.2038 mL
- 1.0191 mL
- 2.0382 mL

技术信息

CAS号

898044-15-0

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H30N8OS

运输

蓝冰

分子量

490.62

别名

PF-03758309;PF-309

溶解度

DMSO	97.0 mg/mL (197.7 mM)
Water	Insoluble
Ethanol	97.0 mg/mL (197.7 mM)

动物实验配方

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