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CAS No.: 92-84-2

吩噻嗪 Catalog No. CSN11693

Synonyms: ENT 38;NSC 2037;NSC-2037 NSC2037

Phenothiazine, a dopamine2 (D2) receptor antagonist, could reduce the expression of dopamine in the brain.

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生物活性

描述Phenothiazines are associated with elevated serum prolactin, which can suppress fertility in some species. Long-acting neuroleptic drugs reduce the adrenal stress response, but may interfere with reproductive responses and negatively influence breeding success^[3]. Clinical use of N-substituted phenothiazines as antihistaminics (1940s), sedatives and antipsychotics (1950s) followed and continues to this day^[4]. The synthesis of a series of novel phenothiazine compounds that inhibit the growth of both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The more potent phenothiazine derivatives were more active against chloroquine-sensitive parasites than against chloroquine-resistant parasites and showed little synergy of action when used in combination with chloroquine^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00080444	Vomiting	Phase 3	Completed	-	-
NCT00499746	-	-	Completed	-	-
NCT00499746	Opioid Abuse ... more >>Opioid Addiction Stimulant Abuse Stimulant Addiction Collapse <<	Phase 1 Phase 2	Completed	-	United States, Maryland ... more >> Behavioral Pharmacology Research Unit Baltimore, Maryland, United States, 21224 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0183 mL
- 25.0916 mL
- 50.1832 mL
- 5 mM
- 1.0037 mL
- 5.0183 mL
- 10.0366 mL
- 10 mM
- 0.5018 mL
- 2.5092 mL
- 5.0183 mL

技术信息

CAS号

92-84-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H9NS

运输

蓝冰

分子量

199.27

别名

ENT 38;NSC 2037;NSC-2037 NSC2037;吩噻嗪;Thiodiphenylamine

溶解度

DMSO	290.0 mg/mL (1455.3 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00080444	Vomiting	Phase 3	Completed	-	-
NCT00499746	-	-	Completed	-	-
NCT00499746	Opioid Abuse ... more >>Opioid Addiction Stimulant Abuse Stimulant Addiction Collapse <<	Phase 1 Phase 2	Completed	-	United States, Maryland ... more >> Behavioral Pharmacology Research Unit Baltimore, Maryland, United States, 21224 Collapse <<
NCT01405924	Nausea Vomiti... more >>ng Collapse <<	Phase 2	Terminated(Low enrollment)	-	-
NCT01405924	-	-	Terminated(Low enrollment)	-	-
NCT03074136	Teeth, Endodontically-Treated	Phase 2	Completed	-	Serbia ... more >> Faculty of Dental Medicine Belgrade, Serbia Collapse <<
NCT01594749	Chemotherapy-Induced Nausea an... more >>d Vomiting (CINV) Collapse <<	Phase 3	Completed	-	-
NCT00216736	-	-	Completed	-	-
NCT00373919	Esophagectomy ... more >> Postoperative Complications Collapse <<	Not Applicable	Unknown	-	-
NCT02734784	Chronic Periodontitis	Phase 4	Completed	-	-
NCT03039244	Chronic Periodontitis	Not Applicable	Completed	-	Brazil ... more >> Mariana Sales Ribeirao Preto, São Paulo, Brazil, 14025710 Collapse <<
NCT01594749	-	-	Completed	-	-
NCT00216736	Migraine	Phase 4	Completed	-	Australia, Victoria ... more >> Department of Emergency Medicine, Western Health Melbourne, Victoria, Australia, 3011 Collapse <<
NCT03498404	Chronic Periodontitis	Phase 4	Completed	-	Brazil ... more >> University of Sao Paulo São Paulo, Sao Paulo, Brazil, 14040-904 Collapse <<
NCT02049008	Aggressive Periodontitis	Phase 4	Completed	-	Brazil ... more >> School of Dentistry of Ribeirao Preto - University of São Paulo Ribeirão Preto, São Paulo, Brazil, 14040-904 Collapse <<

吩噻嗪 Catalog No. CSN11693

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