|苯基双胍|CsnPharm

CAS No.: 102-02-3

Phenylbiguanide/苯基双胍 Catalog No. CSN27301

Synonyms: N-Phenylbiguanide;PBG;1-Phenylbiguanide

Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.

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技术信息

生物活性

描述Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b), respectively^[4]. PBG (Phenylbiguanide) (10 μg/kg) produced hypotension, bradycardia and apnoea-bradypnoea^[5]. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01)^[6]. Intra-atrial injection of PBG produced a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression. In addition, c-Fos expression in the crescent part of the lateral parabrachial nucleus was decreased in PBG-injected mice whereas no significant differences were detected between PBG-injected and control mice in the number of c-Fos-positive nuclei in the dorsal part of the lateral parabrachial nucleus^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.6431 mL
- 28.2157 mL
- 56.4314 mL
- 5 mM
- 1.1286 mL
- 5.6431 mL
- 11.2863 mL
- 10 mM
- 0.5643 mL
- 2.8216 mL
- 5.6431 mL

技术信息

CAS号

102-02-3

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H11N5

运输

蓝冰

分子量

177.21

别名

N-Phenylbiguanide;PBG;1-Phenylbiguanide

溶解度

DMSO	33.0 mg/mL (186.2 mM)
Water	33.0 mg/mL (186.2 mM)
Ethanol	16.0 mg/mL (90.3 mM)

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