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CAS No.: 1075-06-5

苯乙二醛水合物 Catalog No. CSN21792

Synonyms: Phenylglyoxal hydrate

Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.

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技术信息

生物活性

描述Phenylglyoxal H2O is a reagent specific for the modification of arginyl residues in proteins. The resulting arginine-phenylglyoxal adduct can lead to either suppression or induction of permeability transition, depending on the net charge and hydrogen bonding capacity of the adduct by both isolated mitochondria and mammalian cells. When mammalian cells were incubated with low concentrations of negatively charged phenylglyoxal derivatives, the addition of oligomycin caused a depolarization of the mitochondrial membrane potential^[1]. Chloride exchange in resealed human erythrocyte ghosts can be irreversibly inhibited with phenylglyoxal. At 0 degrees C, inhibition is instantaneous and fully reversible, whereas at higher temperature in an alkaline extracellular medium, covalent binding of phenylglyoxal leads to an irreversible inhibition of the transport membranes system. The rate of modification of anion transport depends on phenylglyoxal concentration, pH, temperature, and the presence of anions and reversible inhibitors of the anion transport system in fashions^[2]. Pretreatment of human neutrophils with 100 microgram phenylglyoxal/ml for 30 min at 37 degrees C resulted in almost complete inhibition of phagocytosis of opsonized zymosan. Phenylglyoxal can be used effectively in the bacterial-killing test of phagocytes to inhibit intracellular killing after an initial period of ingestion^[3]. Chemical modification of the Ca(2+)-ATPase with phenylglyoxal, as a modifier of arginine residues, leads to an almost total loss of the ATPase activity^[4].
参考文献

[1] Johans M, Milanesi E, Franck M, Johans C, Liobikas J, Panagiotaki M, Greci L, Principato G, Kinnunen PK, Bernardi P, Costantini P, Eriksson O. Modification of permeability transition pore arginine(s) by phenylglyoxal derivatives in isolated mitochondria and mammalian cells. Structure-function relationship of arginine ligands. J Biol Chem. 2005 Apr 1;280(13):12130-6
[2] Wieth JO, Bjerrum PJ, Borders CL Jr. Irreversible inactivation of red cell chloride exchange with phenylglyoxal, and arginine-specific reagent. J Gen Physiol. 1982 Feb;79(2):283-312
[3] van Schaik ML, Weening RS, Roos D. Phenylglyoxal is not a selective inhibitor of phagocytosis. J Cell Sci. 1979 Aug;38:331-43
[4] Corbalán-García S, Teruel JA, Gómez-Fernández JC. Involvement of an arginyl residue in the nucleotide-binding site of Ca(2+)-ATPase from sarcoplasmic reticulum as seen by reaction with phenylglyoxal. Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):179-85

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.5726 mL
- 32.8629 mL
- 65.7258 mL
- 5 mM
- 1.3145 mL
- 6.5726 mL
- 13.1452 mL
- 10 mM
- 0.6573 mL
- 3.2863 mL
- 6.5726 mL

技术信息

CAS号

1075-06-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H8O3

运输

蓝冰

分子量

152.15

别名

Phenylglyoxal hydrate

溶解度

DMSO	340.0 mg/mL (2234.7 mM)
Water	insoluble

动物实验配方

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苯乙二醛 水合物 Catalog No. CSN21792

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苯乙二醛水合物 Catalog No. CSN21792