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CAS No.: 85-73-4

Phthalylsulfathiazole/酞磺胺噻唑 Catalog No. CSN11709

Synonyms: N4-Phthalylsulfathiazole;Sulfathalidine;Phthalazol

Phthalylsulfathiazole is a broad-spectrum sulfonamide antimicrobial agent.

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技术信息

生物活性

描述Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug. In vitro experiments showed that phthalylsulphathiazole exerts a bacteriostatic effect against a number of intestinal organisms. A Flexner strain, a Sonne III organism, and a strain of B. coli were completely inhibited in semi-solid and fluid media containing the drug. While phthalylsulphathiazole did not appreciably influence the clinical course of Sonne III dysentery, it reduced considerably the number of cases bacteriologically positive in convalescence^[2]. Phthalylsulfathiazole effects a more rapid reduction of Escherichia coli, vegetative forms of the clostridia and related organisms in the feces than does succinylsulfa- thiazole; that the feces become soft but that a diarrhea or semiliquid stool is not produced; that it is effective even in the presence of a watery diarrhea; that it is poorly absorbed from the intestinal tract; that little or no toxicity has been observed and that the dose in comparison with Succinylsulfathiazole is relatively small^[3].
参考文献

[1] BRIMBERG J. Phthalylsulfathiazole, a cause of ureteral obstruction. N Y State J Med. 1958 Aug 1;58(15):2573-5.
[2] Brodie J, Cook RP, Drysdale CF, McIntosh DG. Treatment of Bacillary Dysentery with Phthalylsulphathiazole. Br Med J. 1946;1(4459):948‐950
[3] ANGELO G. Phthalylsulfathiazole-sulfathidine; a clinical evaluation in 122 patients with proctologic and related conditions. Am J Surg. 1945;70:354‐359

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4787 mL
- 12.3937 mL
- 24.7873 mL
- 5 mM
- 0.4957 mL
- 2.4787 mL
- 4.9575 mL
- 10 mM
- 0.2479 mL
- 1.2394 mL
- 2.4787 mL

技术信息

CAS号

85-73-4

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H13N3O5S2

运输

蓝冰

分子量

403.43

别名

N4-Phthalylsulfathiazole;Sulfathalidine;Phthalazol;酞磺胺噻唑;邻苯二甲磺胺噻唑

溶解度

DMSO	215.0 mg/mL (532.9 mM)
Water	insoluble

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Phthalylsulfathiazole/酞磺胺噻唑 Catalog No. CSN11709

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