CAS No.: 883046-50-2
Pichromene Catalog No. CSN20521
S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Yin SQ, Shi M, et al. Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3314-9.
- [2] Mao X, Cao B, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 883046-50-2 | 储存条件 |
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| 分子式 | C17H14FNO4 | 运输 | 蓝冰 | |
| 分子量 | 315.30 | 别名 |
