CAS No.: 957054-33-0
Pictilisib dimethanesulfonate Catalog No. CSN18636
Synonyms: GDC-0941 dimethanesulfonate;GDC-0941 2 MeSO3H salt;Pictilisib Dimethanesulfonate
GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Wallin JJ, Guan J, et al. GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo. Clin Cancer Res. 2012 Jul 15;18(14):3901-11.
- [2] Burrows N, Babur M, et al. GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways. J Clin Endocrinol Metab. 2011 Dec;96(12):E1934-43.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 957054-33-0 | 储存条件 |
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| 分子式 | C25H35N7O9S4 | 运输 | 蓝冰 | |
| 分子量 | 705.85 | 别名 | GDC-0941 dimethanesulfonate;GDC-0941 2 MeSO3H salt;Pictilisib Dimethanesulfonate;Pictilisib mesylate;GDC-0941;RG-7321;GNE-0941;Pictrelisib;Pictilisib |
